[HTML][HTML] The limitless future of RNA therapeutics

TR Damase, R Sukhovershin, C Boada… - … in bioengineering and …, 2021 - frontiersin.org
Recent advances in the generation, purification and cellular delivery of RNA have enabled
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …

[HTML][HTML] Mesoporous silica nanoparticles for drug and gene delivery

Y Zhou, G Quan, Q Wu, X Zhang, B Niu, B Wu… - … pharmaceutica sinica B, 2018 - Elsevier
Mesoporous silica nanoparticles (MSNs) are attracting increasing interest for potential
biomedical applications. With tailored mesoporous structure, huge surface area and pore …

Applications and biocompatibility of mesoporous silica nanocarriers in the field of medicine

C Zhang, H Xie, Z Zhang, B Wen, H Cao… - Frontiers in …, 2022 - frontiersin.org
Mesoporous silica nanocarrier (MSN) preparations have a wide range of medical
applications. Studying the biocompatibility of MSN is an important part of clinical …

[HTML][HTML] Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment

L Jiang, Y Qi, L Yang, Y Miao, W Ren, H Liu… - Asian Journal of …, 2023 - Elsevier
How to effectively transform the pro-oncogenic tumor microenvironments (TME) surrounding
a tumor into an anti-tumoral never fails to attract people to study. Small interfering RNA …

Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

RR Castillo, A Baeza, M Vallet-Regí - Biomaterials science, 2017 - pubs.rsc.org
The discovery and control of the biological roles mediated by nucleic acids have turned
them into a powerful tool for the development of advanced biotechnological materials. Such …

Mesoporous silica nanoparticles: An emerging approach in overcoming the challenges with oral delivery of PPs

SR Pamshong, D Bhatane, S Sarnaik… - Colloids and Surfaces B …, 2023 - Elsevier
Proteins and peptides (PPs), as therapeutics are widely explored in the past few decades,
by virtue of their inherent advantages like high specificity and biocompatibility with minimal …

Novel drug and gene delivery system and imaging agent based on marine diatom biosilica nanoparticles

HA Hussein, MS Nazir, N Azra, Z Qamar, A Seeni… - Marine Drugs, 2022 - mdpi.com
Mesoporous silica nanoparticles (MSNs) have great potential for applications as a drug
delivery system (DDS) due to their unique properties such as large pore size, high surface …

Silica-based gene delivery systems: From design to therapeutic applications

AM Carvalho, RA Cordeiro, H Faneca - Pharmaceutics, 2020 - mdpi.com
Advances in gene therapy have been foreshadowing its potential for the treatment of a vast
range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and …

Potential applications of mesoporous silica nanoparticles for the treatment of neurological disorders

D Bhatane, SR Pamshong, S Sarnaik… - Journal of Drug Delivery …, 2023 - Elsevier
In the current scenario neurological disorders are an emerging threat to public health. These
disorders affect neuronal functions and produce symptoms such as cognitive dysfunction …

[HTML][HTML] Mesoporous silica nanoparticles as carriers for intracellular delivery of nucleic acids and subsequent therapeutic applications

W Cha, R Fan, Y Miao, Y Zhou, C Qin, X Shan, X Wan… - Molecules, 2017 - mdpi.com
Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and
antisense oligonucleotide (ASO), are powerful gene regulators, which have been …