Importance Topical calcineurin inhibitors (TCIs) are commonly used as second-line
treatment for atopic dermatitis. In 2006, the US Food and Drug Administration issued a black …

Over the past 20 years, various studies have demonstrated a pivotal role of T-type calcium
channels (TTCCs) in tumor progression. Cytotoxic effects of TTCC pharmacological blockers …

Nearly two million cases of cutaneous squamous cell carcinoma (cSCC) are diagnosed
every year in the United States alone. cSCC is notable for both its prevalence and its …

Thymic stromal lymphopoietin (TSLP) is a key player in atopic diseases, which has sparked
great interest in therapeutically targeting TSLP. Yet, no small-molecule TSLP inhibitors exist …

Purpose: An increased risk to develop cancer is one of the most challenging negative side
effects of long-term immunosuppression in organ transplant recipients and impaired cancer …

Calcineurin is a calcium-and calmodulin-dependent serine/threonine protein phosphatase
that connects the Ca2+-dependent signalling to multiple cellular responses. Calcineurin …

Background Previous studies have shown conflicting evidence regarding the incidence of
cancer in patients with systemic lupus erythematosus (SLE) compared with that in healthy …

Calcineurin inhibitors (CNIs) are vital immunosuppressive therapies in the management of
inflammatory conditions. A long-term consequence is nephrotoxicity. In the kidneys, the …

Background Calcineurin inhibitors, including tacrolimus, remain a cornerstone of
immunosuppressive therapy after kidney transplantation. However, the therapeutic window …

Background Organ transplant recipients (OTR) are more likely to develop skin cancer than
the general population. One of the main components of the exposome that triggers the …