Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

Sepsis is characterized as a life-threatening organ dysfunction syndrome that is caused by a
dysregulated host response to infection. The main etiological causes of sepsis are bacterial …

The current state-of-the-art tests for infection with Mycobacterium tuberculosis–the IFN-γ
release assays–rely on accurate measurement of the cytokine IFN-γ. Many other potential …

Sepsis is a serious medical condition that occurs in 30% of patients in intensive care units
(ICUs). Early detection of sepsis is key to prevent its progression to severe sepsis and septic …

Problem To determine whether amniotic fluid (AF) CXCL 10 concentration is associated with
histologic chronic chorioamnionitis in patients with preterm labor (PTL) and preterm prelabor …

Introduction Septic shock is a major life-threatening condition in critically ill patients and it is
well known that early recognition of septic shock and expedient initiation of appropriate …

Objective To identify biomarkers which distinguish severe sepsis/septic shock from
uncomplicated sepsis in the Emergency Department (ED). Methods Patients with sepsis …

Sepsis is a heterogeneous disease with variable clinical course and several clinical
phenotypes. As it is associated with an increased risk of death, patients with this condition …

High molecular group box 1 (HMGB1) is a highly conserved member of the HMG-box-family;
abundantly expressed in almost all human cells and released in apoptosis; necrosis or by …

Increased morbidity and mortality after polytrauma due to multiple organ failure (MOF) is a
major concern for clinicians. Systemic inflammatory response syndrome (SIRS) and sepsis …