[HTML][HTML] Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19

CS Whyte, GB Morrow, JL Mitchell, P Chowdary… - Journal of Thrombosis …, 2020 - Elsevier
The global pandemic of coronavirus disease 2019 (COVID‐19) is associated with the
development of acute respiratory distress syndrome (ARDS), which requires ventilation in …

Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach

G Morris, CC Bortolasci, BK Puri, L Olive, W Marx… - Life sciences, 2020 - Elsevier
In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …

[HTML][HTML] Diagnosis and treatment of acute pulmonary inflammation in critically ill patients: the role of inflammatory biomarkers

S Chalmers, A Khawaja, PM Wieruszewski… - World journal of …, 2019 - ncbi.nlm.nih.gov
Pneumonia and acute respiratory distress syndrome are common and important causes of
respiratory failure in the intensive care unit with a significant impact on morbidity, mortality …

Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome

Y Le Tulzo, C Pangault, A Gacouin, V Guilloux, O Tribut… - Shock, 2002 - journals.lww.com
The role of lymphocyte apoptosis in septic shock remains a controversial issue. Using
Annexin V and flow cytometry analysis on freshly isolated cells, we evaluated circulating …

Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-κB pathway in vivo and in vitro

W Jing, M Chunhua, W Shumin - Toxicology and Applied Pharmacology, 2015 - Elsevier
The purpose of the present study was to investigate the protective role of acteoside (AC) on
lipopolysaccharide (LPS)-induced acute lung injury (ALI). BalB/c mice intraperitoneally …

Neutrophils as early immunologic effectors in hemorrhage-or endotoxemia-induced acute lung injury

E Abraham, A Carmody, R Shenkar… - American Journal of …, 2000 - journals.physiology.org
Acute lung injury is characterized by accumulation of neutrophils in the lungs, accompanied
by the development of interstitial edema and an intense inflammatory response. To assess …

Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB

T Zhu, D Wang, W Zhang, X Liao, X Guan, H Bo, J Sun… - PloS one, 2013 - journals.plos.org
Background Nuclear factor-κB (NF-κB) is a central transcriptional factor and a pleiotropic
regulator of many genes involved in acute lung injury. Andrographolide is found in the plant …

[HTML][HTML] Acute respiratory distress syndrome: pathophysiology and therapeutic options

C Pierrakos, M Karanikolas, S Scolletta… - Journal of clinical …, 2012 - ncbi.nlm.nih.gov
Abstract Acute Respiratory Distress Syndrome (ARDS) is a common entity in critical care.
ARDS is associated with many diagnoses, including trauma and sepsis, can lead to multiple …

Invited review: mechanisms of ventilator-induced lung injury: a perspective

CC Dos Santos, AS Slutsky - Journal of applied physiology, 2000 - journals.physiology.org
Despite advances in critical care, the mortality rate in patients with acute lung injury remains
high. Furthermore, most patients who die do so from multisystem organ failure. It has been …