Olutasidenib: from bench to bedside
S Venugopal, J Watts - Blood advances, 2023 - ashpublications.org
The discovery of isocitrate dehydrogenase 1 (IDH1) mutations in acute myeloid leukemia
(AML) and the resounding success of molecularly targeted therapies in related myeloid …
(AML) and the resounding success of molecularly targeted therapies in related myeloid …
Biological roles and therapeutic applications of IDH2 mutations in human cancer
J Guo, R Zhang, Z Yang, Z Duan, D Yin… - Frontiers in oncology, 2021 - frontiersin.org
Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of
isocitrate to α-ketoglutarate (α-KG). Mutations in IDH lead to loss of normal enzymatic activity …
isocitrate to α-ketoglutarate (α-KG). Mutations in IDH lead to loss of normal enzymatic activity …
Machine learning integrates genomic signatures for subclassification beyond primary and secondary acute myeloid leukemia
Although genomic alterations drive the pathogenesis of acute myeloid leukemia (AML),
traditional classifications are largely based on morphology, and prototypic genetic founder …
traditional classifications are largely based on morphology, and prototypic genetic founder …
Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis
S Zarnegar-Lumley, TA Alonzo, RB Gerbing… - Blood …, 2023 - ashpublications.org
Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult acute
myeloid leukemia (AML) and less commonly in pediatric AML. The objective of this study …
myeloid leukemia (AML) and less commonly in pediatric AML. The objective of this study …
Genomics of deletion 7 and 7q in myeloid neoplasm: from pathogenic culprits to potential synthetic lethal therapeutic targets
Complete or partial deletions of chromosome 7 (-7/del7q) belong to the most frequent
chromosomal abnormalities in myeloid neoplasm (MN) and are associated with a poor …
chromosomal abnormalities in myeloid neoplasm (MN) and are associated with a poor …
Prognostic significance of concurrent gene mutations in intensively treated patients with IDH-mutated AML: an ALFA study
M Duchmann, JB Micol, N Duployez… - Blood, The Journal …, 2021 - ashpublications.org
In patients with isocitrate dehydrogenase (IDH)–mutated acute myeloid leukemia (AML)
treated by intensive chemotherapy (IC), prognostic significance of co-occurring genetic …
treated by intensive chemotherapy (IC), prognostic significance of co-occurring genetic …
Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study
Mutations of the isocitrate dehydrogenase-1 (IDH1) and IDH2 genes are among the most
frequent alterations in acute myeloid leukemia (AML) and can be found in∼ 20% of patients …
frequent alterations in acute myeloid leukemia (AML) and can be found in∼ 20% of patients …
Impact of IDH1 and IDH2 mutation detection at diagnosis and in remission in patients with AML receiving allogeneic transplantation
M Bill, M Jentzsch, L Bischof, J Kohlschmidt… - Blood …, 2023 - ashpublications.org
Somatic mutations in the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) are
common in acute myeloid leukemia (AML). The prognostic impact of the presence of IDH …
common in acute myeloid leukemia (AML). The prognostic impact of the presence of IDH …
Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells
Mutations in IDH1, IDH2, and TET2 are recurrently observed in myeloid neoplasms. IDH1
and IDH2 encode isocitrate dehydrogenase isoforms, which normally catalyze the …
and IDH2 encode isocitrate dehydrogenase isoforms, which normally catalyze the …
Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation
Background The role of allogeneic hematopoietic cell transplantation (alloHCT) in acute
myeloid leukemia (AML) with mutated IDH1/2 has not been defined. Therefore, we analyzed …
myeloid leukemia (AML) with mutated IDH1/2 has not been defined. Therefore, we analyzed …