Resistance of pathogenic microorganisms against antimicrobials is a major threat to
contemporary human society. It necessitates a perpetual influx of novel antimicrobial …

More than 300 million people suffer from the incidence of life‐threatening invasive fungal
infections, resulting in over 1.35 million deaths annually. Currently, the antifungal agents …

Previous studies showed that the FeII/α‐ketoglutarate dependent dioxygenase AsqJ induces
a skeletal rearrangement in viridicatin biosynthesis in Aspergillus nidulans, generating a …

The serine peptidase CLPP is conserved among bacteria, chloroplasts, and mitochondria. In
humans and mice, its loss causes Perrault syndrome, which presents with growth deficits …

Cyclopenol (1) and viridicatol (6) with m-hydroxyl groups were isolated from a culture of
Penicillium palitans. Genome mining and heterologous expression in Aspergillus nidulans …

Marine-derived fungi proved to be a rich source of biologically active compounds. The
genus Penicillium has been extensively studied regarding their secondary metabolites and …

The fungal dioxygenase AsqJ catalyses the conversion of benzo [1, 4] diazepine-2, 5-diones
into quinolone antibiotics. A second, alternative reaction pathway leads to a different …

The strong antibacterial, antiviral and anticancer activities demonstrated by quinolones
make them promising lead structures and important synthetic targets for drug discovery …

Nature has developed complexity-generating reactions within natural product biosynthetic
pathways. However, direct utilization of these pathways to prepare compound libraries …

Quinolone-containing natural products are widely found in bacteria, fungi, and plants. The
fungal quinolactacins, which are N-methyl-4-quinolones, display a wide spectrum of …