Spray congealing: An emerging technology to prepare solid dispersions with enhanced oral bioavailability of poorly water soluble drugs

S Bertoni, B Albertini, N Passerini - Molecules, 2019 - mdpi.com
The low and variable oral bioavailability of poorly water soluble drugs remains a major
concern for the pharmaceutical industry. Spray congealing is an emerging technology for the …

[PDF][PDF] Antiparasitic properties of curcumin: A review

K Cheraghipour, A Marzban, B Ezatpour… - AIMS Agric …, 2018 - academia.edu
Antiparasitic properties of curcumin: A review Page 1 AIMS Agriculture and Food, 3(4): 561–578.
DOI:10.3934/agrfood.2018.4.561 Received: 28 September 2018 Accepted: 21 December 2018 …

[HTML][HTML] Praziquantel Meets Niclosamide: A Dual-Drug Antiparasitic Cocrystal

I D'Abbrunzo, E Bianco, L Gigli, N Demitri… - International journal of …, 2023 - Elsevier
In this paper we report a successful example of combining drugs through cocrystallization.
Specifically, the novel solid is formed by two anthelminthic drugs, namely praziquantel (PZQ) …

Thermal-induced impact on physicochemical property and bioaccessibility of β-carotene in aqueous suspensions fabricated by wet-milling approach

L Zhang, W Liao, Y Wang, Z Tong, Q Li, Y Gao - Food Control, 2022 - Elsevier
The physicochemical properties of β-carotene in aqueous system were scarcely explored
before. Herein, β-carotene aqueous suspensions were fabricated by wet-milling, and the …

Mechanochemical formation of racemic praziquantel hemihydrate with improved biopharmaceutical properties

D Zanolla, D Hasa, M Arhangelskis… - Pharmaceutics, 2020 - mdpi.com
Praziquantel (PZQ) is the first-line drug used against schistosomiasis, one of the most
common parasitic diseases in the world. A series of crystalline structures including two new …

Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid

D Zanolla, L Gigli, D Hasa, MR Chierotti… - Pharmaceutics, 2021 - mdpi.com
Two new solvates of the widely used anthelminthic Praziquantel (PZQ) were obtained
through mechanochemical screening with different liquid additives. Specifically, 2 …

Transformation under pressure: Discovery of a novel crystalline form of anthelmintic drug Praziquantel using high-pressure supercritical carbon dioxide

L MacEachern, A Kermanshahi-Pour… - International Journal of …, 2022 - Elsevier
Supercritical carbon dioxide (CO 2) has been used as a processing technique to control
polymorphism of pharmaceuticals. However, there are fewer reports of novel polymorphs …

Drug–polymer compatibility prediction via COSMO-RS

A Mathers, M Fulem - International Journal of Pharmaceutics, 2024 - Elsevier
In this work, the solid–liquid equilibrium (SLE) curve for ten active pharmaceutical
ingredients (APIs) with the polymer polyvinylpyrrolidone (PVP) K12 was purely predicted …

Exploring mechanochemical parameters using a DoE approach: Crystal structure solution from synchrotron XRPD and characterization of a new praziquantel …

D Zanolla, B Perissutti, PC Vioglio, MR Chierotti… - European Journal of …, 2019 - Elsevier
A rotated Doehlert matrix was utilized to explore the experimental design space around the
milling parameters of Praziquantel (PZQ) polymorph B formation in terms of frequency and …

Praziquantel Fifty Years on: A Comprehensive Overview of Its Solid State

I D'Abbrunzo, G Procida, B Perissutti - Pharmaceutics, 2023 - mdpi.com
This review discusses the entire progress made on the anthelmintic drug praziquantel,
focusing on the solid state and, therefore, on anhydrous crystalline polymorphs, amorphous …