Growing evidence suggests the importance of the small intestinal bacteria in the diet–host–
microbiota dialogue in various facets of health and disease. Yet, this body site is still poorly …

The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …

Human intestinal organoids (HIOs) derived from pluripotent stem cells provide a valuable
model for investigating human intestinal organogenesis and physiology, but they lack the …

In a recent issue of the Lancet, the prevalence of Inflammatory Bowel Disease (IBD) was
estimated at 7 million worldwide. Overall, the burden of IBD is rising globally, with direct and …

Biofilm formation is generally recognized as a bacterial defense mechanism against
environmental threats, including antibiotics, bacteriophages, and leukocytes of the human …

Regulatory T cell (Treg) therapy is a promising strategy to treat inflammatory bowel disease
(IBD). Data from animal models has shown that Tregs specific for intestinal antigens are …

Organoids are a new type of 3D model for tumor research, which makes up for the
shortcomings of cell lines and xenograft models, and promotes the development of …

The surfaces of human internal organs are lined by a mucus layer that ensures symbiotic
relationships with commensal microbiome while protecting against potentially injurious …

Digestive system diseases arise primarily through the interplay of genetic and environmental
influences; there is an urgent need in elucidating the pathogenic mechanisms of these …

Simple Summary Colorectal cancer is the third most commonly diagnosed cancer. Patients
may receive chemotherapy, targeted therapy, immunotherapy, radiotherapy, and/or surgery …