Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury

T Huynh, C Reed, Z Blackwell, P Phelps… - Scientific Reports, 2023 - nature.com
This study was designed to test the hypothesis that in addition to repairing the architectural
and cellular cues via regenerative medicine, the delivery of immune cues (immunotherapy) …

The influence of microbial colonization on inflammatory versus pro-healing trajectories in combat extremity wounds

SA Schobel, ER Gann, D Unselt, SF Grey, FA Lisboa… - Scientific reports, 2024 - nature.com
A combination of improved body armor, medical transportation, and treatment has led to the
increased survival of warfighters from combat extremity injuries predominantly caused by …

[PDF][PDF] Unraveling the complex relationship between mRNA and protein abundances: a machine learning-based approach for imputing protein levels from RNA-seq …

A Prabahar, R Zamora, D Barclay, J Yin… - NAR Genomics and …, 2024 - academic.oup.com
The correlation between messenger RNA (mRNA) and protein abundances has long been
debated. RNA sequencing (RNA-seq), a high-throughput, commonly used method for …

[HTML][HTML] Artificial Intelligence Optical Biopsy for Evaluating the Functional State of Wounds

J Teague, D Socia, G An, S Badylak, S Johnson… - Journal of Surgical …, 2023 - Elsevier
Introduction The clinical characterization of the functional status of active wounds in terms of
their driving cellular and molecular biology remains a considerable challenge that currently …

Uncovering the Effects of Genes, Proteins, and Medications on Functions of Wound Healing: A Dependency Rule-Based Text Mining Approach Leveraging GPT-4 …

JH Jui, M Hauskrecht - 2023 IEEE EMBS International …, 2023 - ieeexplore.ieee.org
Wound healing is a complex biological process characterized by intricate cellular and
molecular interactions. Understanding the underlying mechanisms and the effects of …

The Wound Environment Agent-based Model (WEABM): a digital twin platform for characterization and complex therapeutic discovery for volumetric muscle loss

C Cockrell, Y Vodovotz, R Zamora, G An - bioRxiv, 2024 - biorxiv.org
Abstract Volumetric Muscle Loss (VML) injuries are characterized by significant loss of
muscle mass, usually due to trauma or surgical resection, often with a residual open wound …

Harnessing the Power of Large Language Models (LLMs) to Unravel the Influence of Genes and Medication on Biological Processes of Wound Healing

JH Jui, M Hauskrecht - bioRxiv, 2024 - biorxiv.org
Recent advancements in Large Language Models (LLMs) have ushered in a new era for
knowledge extraction in the domains of biological and clinical natural language processing …