Secretory Phospholipases A2, from Snakebite Envenoming to a Myriad of Inflammation Associated Human Diseases—What Is the Secret of Their Activity?
F Tonello - International Journal of Molecular Sciences, 2023 - mdpi.com
Secreted phospholipases of type A2 (sPLA2s) are proteins of 14–16 kDa present in
mammals in different forms and at different body sites. They are involved in lipid …
mammals in different forms and at different body sites. They are involved in lipid …
Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A2
M Mangini, R D'angelo, C Vinciguerra… - Frontiers in Cell and …, 2022 - frontiersin.org
Increasing evidence points to the involvement of group IIA secreted phospholipase A2
(sPLA2-IIA) in pathologies characterized by abnormal osteoclast bone-resorption activity …
(sPLA2-IIA) in pathologies characterized by abnormal osteoclast bone-resorption activity …
Identification of a Dual Inhibitor of Secreted Phospholipase A2 (GIIA sPLA2) and SARS-CoV-2 Main Protease
MA Theodoropoulou, GS Koutoulogenis, L Zhang… - Pharmaceuticals, 2022 - mdpi.com
The development of novel agents to combat COVID-19 is of high importance. SARS-CoV-2
main protease (Mpro) is a highly attractive target for the development of novel antivirals and …
main protease (Mpro) is a highly attractive target for the development of novel antivirals and …
Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs
S Janciauskiene, S Tumpara, NH Schebb… - Frontiers in …, 2022 - frontiersin.org
Human alpha-1-antitrypsin (AAT) encoded by the SERPINA1 gene, is an acute phase
glycoprotein that regulates inflammatory responses via both protease inhibitory and non …
glycoprotein that regulates inflammatory responses via both protease inhibitory and non …
Interplay between C1-inhibitor and group IIA secreted phospholipase A2 impairs their respective function
AL Ferrara, M Bova, A Petraroli, D Marasco… - Immunologic …, 2023 - Springer
High levels of human group IIA secreted phospholipase A2 (hGIIA) have been associated
with various inflammatory disease conditions. We have recently shown that hGIIA activity …
with various inflammatory disease conditions. We have recently shown that hGIIA activity …
Metabolomic mechanism and pharmacodynamic material basis of Buxue Yimu pills in the treatment of anaemia in women of reproductive age
G Ying-Ying, W Yan-Fang, D Yan, Z Su-Ying… - Frontiers in …, 2023 - frontiersin.org
Objective: To explore the pharmacological basis and mechanism of Buxue Yimu pills (BYP)
in the treatment of anaemia in women from the perspective of metabolomics and network …
in the treatment of anaemia in women from the perspective of metabolomics and network …