Molecular imaging for non-invasive assessment of angiogenesisis is of great interest for
clinicians because of the wide-spread application of anti-angiogenic cancer therapeutics …

Nanotheranostics, the integration of diagnostic and therapeutic function in one system using
the benefits of nanotechnology, is extremely attractive for personalized medicine. Because …

A new zwitterionic organotrifluoroborate is appended to three radiosynthons that afford
undergo facile bioconjugation to several clinically relevant peptides and one enzyme …

18F-FPPRGD2, which was approved for clinical study recently, has favorable properties for
integrin targeting and showed potential for antiangiogenic therapy and early response …

While the development of positron emission tomography (PET) radiopharmaceuticals
closely follows that of traditional drug development, there are several key considerations in …

Advances in precision molecular imaging promise to transform our ability to detect, diagnose
and treat disease. Here, we describe the engineering and validation of a new cystine knot …

[18F] FPPRGD2, an F-18 labeled dimeric cyclic RGDyK peptide, has favorable properties for
PET imaging of angiogenesis by targeting the αvβ3 integrin receptor. This radiotracer has …

Angiogenesis is a common feature of many physiological processes and pathological
conditions. RGD-containing peptides can strongly bind to integrin αvβ3 expressed on …

Purpose To assess the safety, biodistribution, and dosimetric properties of the positron
emission tomography (PET) radiopharmaceutical agent fluorine 18 (18F) FPPRGD2 (2 …

Herein we present a general protocol for the functionalization of biomolecules with an
organotrifluoroborate moiety so that they can be radiolabeled with aqueous 18F fluoride …