Antiviral drug resistance is a matter of great clinical importance that, historically, has been
investigated mostly from a virological perspective. Although the proximate mechanisms of …

Aligning sequencing reads onto a reference is an essential step of the majority of genomic
analysis pipelines. Computational algorithms for read alignment have evolved in …

Interpreting the results of plasma human immunodeficiency virus type 1 (HIV-1) genotypic
drug-resistance tests is one of the most difficult tasks facing clinicians caring for HIV-1 …

Viral tropism is the ability of viruses to enter and infect specific host cells and is based on the
ability of viruses to bind to receptors on those cells. Testing for HIV tropism is recommended …

Drug resistance is a common cause of treatment failure for HIV infection and cancer. The
high mutation rate of HIV leads to genetic heterogeneity among viral populations and …

The diversity of virus populations within single infected hosts presents a major difficulty for
the natural immune response as well as for vaccine design and antiviral drug therapy …

Analysis of the literature involving computational modeling of diseases and drug design with
the aid of experimental spectroscopic techniques reveals that this specific combination of …

Background RNA viruses infecting a host usually exist as a set of closely related sequences,
referred to as quasispecies. The genomic diversity of viral quasispecies is a subject of great …

The unprecedented coverage offered by next-generation sequencing (NGS) technology has
facilitated the assessment of the population complexity of intra-host RNA viral populations at …

Abstract The Human Immunodeficiency Virus (HIV) is a complex retrovirus that progressively
deteriorates the immune system of infected patients, eventually causing death. Although …