Simple Summary MicroRNAs (miRNAs) are small RNA molecules that regulate gene
expression by blocking translation or inducing degradation of specific gene transcripts. The …

Gene fusions have a pivotal role in non-small cell lung cancer (NSCLC) precision medicine.
Several techniques can be used, from fluorescence in situ hybridization and …

Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based …

Biomarkers have various applications including disease detection, diagnosis, prognosis,
prediction of response to intervention, and disease monitoring. In this era of precision …

Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such
as gefitinib, has greatly affected clinical outcomes in non-small cell lung cancer (NSCLC) …

Purpose Prediction of immunotherapy response and outcome in patients with non-small cell
lung cancer (NSCLC) is challenging due to intratumoral heterogeneity and lack of robust …

Natural killer (NK) cells, as key immune cells, play essential roles in tumor cell immune
escape and immunotherapy. Accumulating evidence has demonstrated that the gut …

The objective of this systematic review was to analyze the current state of the art of imaging-
derived biomarkers predictive of genetic alterations and immunotherapy targets in lung …

Abstract Epidermal Growth Factor Receptor (EGFR), a transmembrane tyrosine kinase
receptor, belongs to the ErbB receptor family, also known as HER1 or ErbB1. Its abnormal …

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are treatments
commonly used for lung cancer. The toxicity profile including toxicity incidence, severity, and …