One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …

Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Abstract Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis
established metabolic reprogramming as one of the first distinguishing characteristics of …

Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …

The efficacy of immunotherapy is limited by the paucity of T cells delivered and infiltrated into
the tumors through aberrant tumor vasculature. Here, we report that phosphoglycerate …

While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …

Breast cancer is the most common malignancy in women worldwide and is associated with
high mortality rates despite the continuously advancing treatment strategies. Glucose is …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

Serine metabolism is reportedly involved in immune cell functions, but whether and how
serine metabolism regulates macrophage polarization remain largely unknown. Here, we …

Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in
cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses …