Total glucosides of paeony: a review of its phytochemistry, role in autoimmune diseases, and mechanisms of action

H Jiang, J Li, L Wang, S Wang, X Nie, Y Chen… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Paeoniae Radix Alba (PRA, called baishao in
China), the root of Paeonia lactiflora Pall., has shown a rich medicinal value for more than …

A review for the anti-inflammatory effects of paeoniflorin in inflammatory disorders

Q Xin, R Yuan, W Shi, Z Zhu, Y Wang, W Cong - Life sciences, 2019 - Elsevier
Inflammatory disorders result from abnormal immune response and their incidence has
increased recently. Thus, there is an urgent need to discover new treatments for …

Paeoniflorin, a natural product with multiple targets in liver diseases—a mini review

X Ma, W Zhang, Y Jiang, J Wen, S Wei… - Frontiers in …, 2020 - frontiersin.org
Paeoniflorin is derived from Paeonia suffruticosa Andr., Paeonia lactiflora Pall., or Paeonia
veitchii Lynch and has been used in traditional medical applications for more than 2,000 …

COVID-19. Pandemic surgery guidance

BLDM Brücher, G Nigri, A Tinelli, J Florencio… - 4 OPEN, 2020 - iris.uniroma1.it
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

[HTML][HTML] CP-25 combined with MTX/LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation

X Yang, Y Zhao, X Jia, C Wang, Y Wu, L Zhang… - Biomedicine & …, 2019 - Elsevier
Objective CP-25 attenuates arthritis progression in animal models by inhibiting G protein-
coupled receptor kinase 2 (GRK2) membrane expression. This study compared groups …

Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models

JK Nono, K Fu, T Mpotje, G Varrone, NA Aziz… - Scientific reports, 2020 - nature.com
Tissue fibrosis underlies the majority of human mortality to date with close to half of all
reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and …

Therapeutic Potential of Natural Products in the Treatment of Schistosomiasis

CM Azevedo, CS Meira, JW da Silva, DMN Moura… - Molecules, 2023 - mdpi.com
It is estimated that 250 million people worldwide are affected by schistosomiasis. Disease
transmission is related to the poor sanitation and hygiene habits that affect residents of …

Chronic schistosomiasis suppresses HIV-specific responses to DNA-MVA and MVA-gp140 Env vaccine regimens despite antihelminthic treatment and increases …

GA Dzhivhuho, SA Rehrl, H Ndlovu… - PLoS …, 2018 - journals.plos.org
Future HIV vaccines are expected to induce effective Th1 cell-mediated and Env-specific
antibody responses that are necessary to offer protective immunity to HIV infection …

A comprehensive review of natural products to fight liver fibrosis: alkaloids, terpenoids, glycosides, coumarins and other compounds

X Ma, Y Jiang, J Wen, Y Zhao, J Zeng, Y Guo - European Journal of …, 2020 - Elsevier
The discovery of drugs to treat liver fibrosis has long been a challenge over the past
decades due to its complicated pathogenesis. As a primary approach for drug development …

[HTML][HTML] Paeoniflorin attenuates DHEA-induced polycystic ovary syndrome via inactivation of TGF-β1/Smads signaling pathway in vivo

J Zhou, Y Tan, X Wang, M Zhu - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Polycystic ovarian syndrome (PCOS) is one of the most common reproductive endocrine
disorders which are involved in complicated and unknown pathogenic mechanisms …