When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

The combinatorial pattern of DNA and histone modifications constitutes an epigenetic 'code
'that shapes gene-expression patterns by enabling or restricting the transcriptional potential …

Chromosome segregation during mitosis requires assembly of the kinetochore complex at
the centromere. Kinetochore assembly depends on specific recognition of the histone …

Revealing the energy landscape for nucleosome association may contribute to the
understanding of higher-order chromatin structures and their impact on genome regulation …

Abstract The small GTPase Ran enzyme regulates critical eukaryotic cellular functions
including nuclear transport and mitosis through the creation of a RanGTP gradient around …

INO80/SWR1 family chromatin remodelers are complexes composed of> 15 subunits and
molecular masses exceeding 1 MDa. Their important role in transcription and genome …

One of the most fundamental questions in the control of gene expression in mammals is how
epigenetic methylation patterns of DNA and histones are established, erased, and …

Chromatin structure and function are regulated by numerous proteins through specific
binding to nucleosomes. The structural basis of many of these interactions is unknown, as in …

Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

In eukaryotes, genomic DNA is compacted in chromatin, which generally suppresses
transcription, replication, repair, and recombination. The fundamental unit of chromatin is the …