Neutrophil nucleus: shaping the past and the future

J Salafranca, JK Ko, AK Mukherjee… - Journal of Leukocyte …, 2023 - academic.oup.com
Neutrophils are innate immune cells that are key to protecting the host against infection and
maintaining body homeostasis. However, if dysregulated, they can contribute to disease …

Experimental and computational framework for a dynamic protein atlas of human cell division

Y Cai, MJ Hossain, JK Hériché, AZ Politi, N Walther… - Nature, 2018 - nature.com
Essential biological functions, such as mitosis, require tight coordination of hundreds of
proteins in space and time. Localization, the timing of interactions and changes in cellular …

Building cell models and simulations from microscope images

RF Murphy - Methods, 2016 - Elsevier
The use of fluorescence microscopy has undergone a major revolution over the past twenty
years, both with the development of dramatic new technologies and with the widespread …

[HTML][HTML] Orientation-invariant autoencoders learn robust representations for shape profiling of cells and organelles

J Burgess, JJ Nirschl, MC Zanellati, A Lozano… - Nature …, 2024 - nature.com
Cell and organelle shape are driven by diverse genetic and environmental factors and thus
accurate quantification of cellular morphology is essential to experimental cell biology …

[HTML][HTML] Inferring cell state by quantitative motility analysis reveals a dynamic state system and broken detailed balance

JC Kimmel, AY Chang, AS Brack… - PLoS computational …, 2018 - journals.plos.org
Cell populations display heterogeneous and dynamic phenotypic states at multiple scales.
Similar to molecular features commonly used to explore cell heterogeneity, cell behavior is a …

Evaluation of methods for generative modeling of cell and nuclear shape

X Ruan, RF Murphy - Bioinformatics, 2019 - academic.oup.com
Motivation Cell shape provides both geometry for, and a reflection of, cell function.
Numerous methods for describing and modeling cell shape have been described, but …

Next‐generation pathology detection of T cell–antigen‐presenting cell immune synapses in human liver allografts

MA Wood‐Trageser, D Lesniak, A Gambella… - Hepatology, 2023 - journals.lww.com
Next‐generation pathology detection of T cell–antigen‐presen... : Hepatology Next‐generation
pathology detection of T cell–antigen‐presenting cell immune synapses in human liver …

[HTML][HTML] An image-based data-driven analysis of cellular architecture in a developing tissue

J Hartmann, M Wong, E Gallo, D Gilmour - elife, 2020 - elifesciences.org
Quantitative microscopy is becoming increasingly crucial in efforts to disentangle the
complexity of organogenesis, yet adoption of the potent new toolbox provided by modern …

Building a 3d integrated cell

GR Johnson, RM Donovan-Maiye, MM Maleckar - BioRxiv, 2017 - biorxiv.org
We present a conditional generative model for learning variation in cell and nuclear
morphology and predicting the location of subcellular structures from 3D microscopy …

[HTML][HTML] Modelling cell shape in 3D structured environments: A quantitative comparison with experiments

R Link, M Jaggy, M Bastmeyer… - PLOS Computational …, 2024 - journals.plos.org
Cell shape plays a fundamental role in many biological processes, including adhesion,
migration, division and development, but it is not clear which shape model best predicts …