Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is
characterized by the concomitant occurrence of often severe thrombocytopenia …

Abstract von Willebrand factor (VWF) is a large adhesive glycoprotein with established
functions in hemostasis. It serves as a carrier for factor VIII and acts as a vascular damage …

The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …

A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of
membrane-anchored multidomain proteinases that are responsible for the shedding of cell …

Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic
microangiopathy which causes significant morbidity and mortality unless promptly …

A disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13) is a
metalloprotease that regulates von Willebrand factor (VWF) function. ADAMTS13-mediated …

Summary ADAMTS‐13, a plasma reprolysin‐like metalloprotease, cleaves von W illebrand
factor (VWF). Severe deficiency of plasma ADAMTS‐13 activity results in thrombotic …

Background Acquired thrombotic thrombocytopenic purpura (TTP) is an autoimmune
disease in which anti-ADAMTS13 autoantibodies cause severe enzyme deficiency …

Platelet recruitment to sites of blood vessel damage is highly dependent upon von
Willebrand factor (VWF). VWF platelet-tethering function is proteolytically regulated by the …