Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis,
nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …

Alzheimer's disease (AD) is a complex neurodegenerative disease, perturbing neuronal and
non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped all …

Spinal cord injury in mammals is thought to trigger scar formation with little regeneration of
axons,,–. Here we show that a crush injury to the spinal cord in neonatal mice leads to scar …

Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing
evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells …

Impaired activation and regulation of the extinction of inflammatory cells and molecules in
injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly …