Due to its genetic tractability and increasing wealth of accessible data, the yeast
Saccharomyces cerevisiae is a model system of choice for the study of the genetics …

The mechanisms whereby ribosomes engage a messenger RNA and select the start site for
translation differ between prokaryotes and eukaryotes. Initiation sites in polycistronic …

Significant progress has been made in the past four decades toward understanding the
structures and synthesis of bioactive peptides produced by microorganisms through the …

The entire pathway of palmitate synthesis from malonyl-CoA in mammals is catalyzed by a
single, homodimeric, multifunctional protein, the fatty acid synthase. Each subunit contains …

Fatty acids are essential compounds in the cell. Since the yeast Saccharomyces cerevisiae
does not feed typically on fatty acids, cellular function and growth relies on endogenous …

Over the last eight years or so, genetic techniques have spearheaded significant advances
in our understanding of the structure and mechanisms of polyketide synthases (PKSs). Much …

ERYTHROMYCIN A, a clinically important polyketide antibiotic, is produced by the Gram-
positive bacterium Saccharopolyspora erythraea.. In an arrangement that seems to be …

The present review focuses on microbial type I fatty acid synthases (FASs), demonstrating
their structural and functional diversity. Depending on their origin and biochemical function …

Stearoyl-acyl-carrier-protein (ACP) desaturase (EC 1.14. 99.6) was purified to homogeneity
from avocado mesocarp, and monospecific polyclonal antibodies directed against the …

CYTOPLASMIC incompatibility (CI) describes the phenomenon whereby eggs fertilized by
sperm from insects infected with a rickettsial endosymbiont fail to hatch. Unidirectional CI …