Role of HBx in hepatitis B virus persistence and its therapeutic implications
BL Slagle, MJ Bouchard - Current opinion in virology, 2018 - Elsevier
Highlights•HBV HBx is required for virus replication.•Required HBx function (s) may vary
with the stage of chronic HBV infection.•HBx binding to DDB1 may impact several DDB1 …
with the stage of chronic HBV infection.•HBx binding to DDB1 may impact several DDB1 …
SAMHD1 functions and human diseases
SAA Coggins, B Mahboubi, RF Schinazi, B Kim - Viruses, 2020 - mdpi.com
Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …
maintenance of genomic information in both cells and a variety of viral pathogens. While the …
SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways
S Chen, S Bonifati, Z Qin, C St. Gelais… - Proceedings of the …, 2018 - National Acad Sciences
Sterile alpha motif and HD-domain–containing protein 1 (SAMHD1) blocks replication of
retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has …
retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has …
[HTML][HTML] Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation
J Hu, Q Gao, Y Yang, J Xia, W Zhang, Y Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Viruses hijack the host cell machinery to promote viral replication; however, the
mechanism by which metabolic reprogramming regulates innate antiviral immunity in the …
mechanism by which metabolic reprogramming regulates innate antiviral immunity in the …
SAMHD1 modulates early steps during human cytomegalovirus infection by limiting NF-κB activation
Cellular SAMHD1 inhibits replication of many viruses by limiting intracellular
deoxynucleoside triphosphate (dNTP) pools. We investigate the influence of SAMHD1 on …
deoxynucleoside triphosphate (dNTP) pools. We investigate the influence of SAMHD1 on …
Src tyrosine kinase inhibitors: new perspectives on their immune, antiviral, and senotherapeutic potential
J Rivera-Torres, E San José - Frontiers in Pharmacology, 2019 - frontiersin.org
Deregulated activity of the Src tyrosine kinases leads to malignant transformation. Since the
FDA approval of the tyrosine kinase inhibitor, imatinib, in 2001 for the treatment of chronic …
FDA approval of the tyrosine kinase inhibitor, imatinib, in 2001 for the treatment of chronic …
Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97
R Businger, J Deutschmann, I Gruska, J Milbradt… - Nature …, 2019 - nature.com
The host restriction factor sterile alpha motif and histidine–aspartate domain-containing
protein 1 (SAMHD1) is an important component of the innate immune system. By regulating …
protein 1 (SAMHD1) is an important component of the innate immune system. By regulating …
TRAF6 and TAK1 contribute to SAMHD1-mediated negative regulation of NF-κB signaling
CE Espada, C St. Gelais, S Bonifati… - Journal of …, 2021 - Am Soc Microbiol
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) restricts HIV-1 replication
by limiting the intracellular deoxynucleoside triphosphate (dNTP) pool. SAMHD1 also …
by limiting the intracellular deoxynucleoside triphosphate (dNTP) pool. SAMHD1 also …
Retroviral restriction factors and their viral targets: restriction strategies and evolutionary adaptations
G Boso, CA Kozak - Microorganisms, 2020 - mdpi.com
The evolutionary conflict between retroviruses and their vertebrate hosts over millions of
years has led to the emergence of cellular innate immune proteins termed restriction factors …
years has led to the emergence of cellular innate immune proteins termed restriction factors …
APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription
Y Chen, J Hu, X Cai, Y Huang, X Zhou, Z Tu, J Hu… - Antiviral Research, 2018 - Elsevier
Hepatitis B virus is a partially double-stranded DNA virus that replicates by reverse
transcription, which occurs within viral core particles in the cytoplasm. The cytidine …
transcription, which occurs within viral core particles in the cytoplasm. The cytidine …