Following prolonged neglect during the formative decades of behavioural neurology, the
temporopolar region has become a site of vibrant research on the neurobiology of cognition …

The lateralization of the human brain may provide clues into the pathogenesis and
progression of neurodegenerative diseases. Though differing in their presentation and …

Primary progressive aphasia is a neurodegenerative disease that selectively impairs
language without equivalent impairment of speech, memory or comportment. In 118 …

Frontotemporal lobar degeneration (FTLD) represents a group of neurodegenerative brain
diseases with highly heterogeneous clinical, neuropathological and genetic characteristics …

Primary progressive aphasia (PPA) is a dementia syndrome associated with several
neuropathologic entities, including Alzheimer's disease (AD) and all major forms of …

Phosphorylated tau (p‐tau) pathology correlates strongly with cognitive decline and is a
pathological hallmark of Alzheimer's Disease (AD). In recent years, phosphorylated …

Genetic forms of frontotemporal dementia are most commonly due to mutations in three
genes, C9orf72, GRN or MAPT, with presymptomatic carriers from families representing …

Frontotemporal lobar degeneration (FTLD) with either tau (FTLD-tau) or TDP-43 (FTLD-TDP)
inclusions are distinct proteinopathies that frequently cause similar frontotemporal dementia …

PURPOSE OF REVIEW This article summarizes the clinical and anatomic features of the
three named variants of primary progressive aphasia (PPA): semantic variant PPA …

Antemortem behavioural and anatomic abnormalities have largely been associated with
right hemisphere disease in behavioural-variant frontotemporal dementia, but post-mortem …