Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them?

JP Mouton, M Blockman… - British Journal of …, 2021 - Wiley Online Library
Patients in sub‐Saharan Africa generally have poor anticoagulation control. We review the
potential reasons for this poor control, as well as the potential solutions. Challenges include …

The genetics of warfarin dose–response variability in Africans: an expert perspective on past, present, and future

A Ndadza, NE Thomford, S Mukanganyama… - Omics: a journal of …, 2019 - liebertpub.com
Coumarins such as warfarin are prescribed for prevention and treatment of thromboembolic
disorders. Warfarin remains the most widely prescribed and an anticoagulant of choice in …

Warfarin pharmacogenomics for precision medicine in real-life clinical practice in southern Africa: Harnessing 73 variants in 29 pharmacogenes

S Muyambo, A Ndadza, ND Soko, B Kruger… - OMICS: A Journal of …, 2022 - liebertpub.com
Pharmacogenomics is universally relevant for worldwide modern therapeutics and yet
needs further development in resource-limited countries. While there is an abundance of …

Evaluating the impact of a 15‐year academic partnership to promote sustainable engagement, education, and scholarship in global health

R Karwa, ML Miller, E Schellhase… - Journal of the …, 2020 - Wiley Online Library
Abstract Introduction In 2003, Purdue University College of Pharmacy (PUCOP) in West
Lafayette, Indiana, began the Purdue Kenya Partnership (PKP) in collaboration with the …

Pregnancy Related Venous Thromboembolism-Associated with HIV Infection and Antiretroviral Therapy

E Schapkaitz, BF Jacobson… - Seminars in Thrombosis …, 2023 - thieme-connect.com
Human immunodeficiency virus (HIV) infection in pregnancy is associated with substantial
morbidity and mortality. Improved access to effective antiretroviral therapy (ART) has shifted …

International Normalized Ratio (INR) Increases amongst Two Patients Living with HIV on Warfarin after Being Switched from a Nevirapine to a Dolutegravir‐Based …

N Sang, S Pastakia, S Nyanje - Case Reports in Infectious …, 2021 - Wiley Online Library
The increased use of dolutegravir‐based regimens in the treatment of HIV is unmasking
drug interactions, particularly in patients who were previously on nevirapine. Nevirapine is …

Pharmacogenomics of warfarin: comprehensive evaluation of important warfarin genomic response factors

A Ndadza - 2023 - open.uct.ac.za
Introduction: Warfarin is the most widely prescribed anticoagulant for the prevention and
treatment of thromboembolic diseases. However, warfarin use is complicated by its narrow …

Venous thromboembolism among people with HIV: Design, implementation, and findings of a centralized adjudication system in clinical care sites across the United …

HM Crane, RM Nance, SA Ruderman… - JAIDS Journal of …, 2022 - journals.lww.com
BACKGROUND: People with HIV (PWH) are at increased risk for venous thromboembolism
(VTE). We conducted this study to characterize VTE including provoking factors among PWH …

Manifestations thromboemboliques chez 36 patients Ouest Africains infectés par le VIH

FN Ello, LD Bawe, GA Kouakou, CM Mossou… - Pan African Medical …, 2018 - ajol.info
Short communication Page 1 Page number not for citation purposes 1 Manifestations
thromboemboliques chez 36 patients Ouest Africains infectés par le VIH Thromboembolic …

Profiles of patients on warfarin anticoagulation therapy in a leading tertiary referral hospital in Kenya; findings and implications for Kenya

DG Nyamu, AN Guantai, GO Osanjo… - Expert Review of …, 2020 - Taylor & Francis
Background: Patients' profiles affect the outcome with warfarin; however, this data, and its
implications, is scarce in resource-poor countries without access to pharmacogenetics or …