The treatment of peripheral nerve defects has always been one of the most challenging
clinical practices in neurosurgery. Currently, nerve autograft is the preferred treatment …

Surgical repair of severe peripheral nerve injuries represents not only a pressing medical
need, but also a great clinical challenge. Autologous nerve grafting remains a golden …

▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …

In spite of an enormous amount of new experimental laboratory data based on evolving
neuroscientific concepts during the last 25 years peripheral nerve injuries still belong to the …

Damage to the peripheral nervous system is surprisingly common and occurs primarily from
trauma or a complication of surgery. Although recovery of nerve function occurs in many mild …

Artificial nerve guide conduits have the advantage over autografts in terms of their
availability and ease of fabrication. However, clinical outcomes associated with the use of …

Nerve tubes, guides, or conduits are a promising alternative for autologous nerve graft
repair. The first biodegradable empty single lumen or hollow nerve tubes are currently …

Biofabrication techniques have endeavored to improve the regeneration of the peripheral
nervous system (PNS), but nothing has surpassed the performance of current clinical …

With significant advances in the research and application of nerve conduits, they have been
used to repair peripheral nerve injury for several decades. Nerve conduits range from …

Nerve injury, a significant cause of disability, may be treated more effectively using nerve
guidance channels containing longitudinally aligned fibers. Aligned, electrospun nanofibers …