Diversity, mechanisms, and significance of macrophage plasticity

M Locati, G Curtale, A Mantovani - Annual Review of Pathology …, 2020 - annualreviews.org
Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy

B Toledo, L Zhu Chen, M Paniagua-Sancho… - Journal of hematology & …, 2024 - Springer
Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours
are known as tumour-associated macrophages (TAMs). These specialized immune cells …

Microglia: agents of the CNS pro-inflammatory response

JA Rodríguez-Gómez, E Kavanagh… - Cells, 2020 - mdpi.com
The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Bidirectional microglia–neuron communication in health and disease

Z Szepesi, O Manouchehrian, S Bachiller… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

A Hammarstedt, S Gogg, S Hedjazifar… - Physiological …, 2018 - journals.physiology.org
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …

Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19

SJ Theobald, A Simonis, T Georgomanolis… - EMBO molecular …, 2021 - embopress.org
Innate immunity triggers responsible for viral control or hyperinflammation in COVID‐19 are
largely unknown. Here we show that the SARS‐CoV‐2 spike protein (S‐protein) primes …

[HTML][HTML] Cell-to-cell communication by extracellular vesicles: focus on microglia

RC Paolicelli, G Bergamini, L Rajendran - Neuroscience, 2019 - Elsevier
Extracellular vesicles, including exosomes and microvesicles, are small, nano-to-micrometer
vesicles that are released from cells. While initially observed in immune cells and …

M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment

S Liu, J Chen, J Shi, W Zhou, L Wang, W Fang… - Basic research in …, 2020 - Springer
The roles and the underlying mechanisms of M1-type macrophages in angiogenesis and
postmyocardial infarction (MI) cardiac repair have remained unclear. In this study, we …

Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins …

G Kwak, J Cheng, H Kim, S Song, SJ Lee, Y Yang… - Small, 2022 - Wiley Online Library
Macrophages (Mφs) are characterized by remarkable plasticity, an essential component of
chronic inflammation. Thus, an appropriate and timely transition from proinflammatory (M1) …

MiR-155: an important regulator of neuroinflammation

VD Zingale, A Gugliandolo, E Mazzon - International Journal of Molecular …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
at the post-transcriptional level and that play an important role in many cellular processes …