The complex anatomy of the epidermis contains multiple adult stem cell populations, but the
extent to which they functionally overlap during homeostasis, wound healing, and tumor …

Background. Optimal treatment decisions for cancer patients require reliable prognostic and
predictive information. However, this information is inadequate in many cases. Several …

Epithelial lineages have been studied at cellular resolution in multiple organs that turn over
rapidly. However, many epithelia, including those of the lung, liver, pancreas, and prostate …

Epithelial organs undergo steady-state turnover throughout adult life, with old cells being
continually replaced by the progeny of stem cell divisions. To avoid hyperplasia or atrophy …

In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed
from the tissue surface and replaced by cell division. Tracking genetically labelled cells in …

Background LRIG1, the founding member of the LRIG (leucine-rich repeat and
immunoglobulin-like domain) family of transmembrane proteins, is a negative regulator of …

Cells of epithelial tissue proliferate and pack together to attain an eventual density
homeostasis. As the cell density increases, spatial distribution of velocity and force show …

The leucine-rich repeats and immunoglobulin-like domains (LRIG) family of transmembrane
proteins contains three vertebrate members (LRIG1, LRIG2 and LRIG3) and one member …

Adult animals rely on populations of stem cells to ensure organ function throughout their
lifetime. Stem cells are governed by signals from stem cell niches, and much is known about …

Recently, a genome-wide association study showed that a single nucleotide polymorphism
(SNP)—rs11706832—in intron 2 of the human LRIG1 (Leucine-rich repeats and …