Structure and immune recognition of trimeric pre-fusion HIV-1 Env
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors
Host proteins are essential for HIV entry and replication and can be important nonviral
therapeutic targets. Large-scale RNA interference (RNAi)-based screens have identified …
therapeutic targets. Large-scale RNA interference (RNAi)-based screens have identified …
Optimal combinations of broadly neutralizing antibodies for prevention and treatment of HIV-1 clade C infection
The identification of a new generation of potent broadly neutralizing HIV-1 antibodies
(bnAbs) has generated substantial interest in their potential use for the prevention and/or …
(bnAbs) has generated substantial interest in their potential use for the prevention and/or …
Targeting HIV reservoir in infected CD4 T cells by dual-affinity re-targeting molecules (DARTs) that bind HIV envelope and recruit cytotoxic T cells
DD Sloan, CYK Lam, A Irrinki, L Liu, A Tsai… - PLoS …, 2015 - journals.plos.org
HIV reservoirs and production of viral antigens are not eliminated in chronically infected
participants treated with combination antiretroviral therapy (cART). Novel therapeutic …
participants treated with combination antiretroviral therapy (cART). Novel therapeutic …
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization
The third variable (V3) loop on the human immunodeficiency virus 1 (HIV-1) envelope
glycoprotein trimer is indispensable for virus cell entry. Conformational masking of V3 within …
glycoprotein trimer is indispensable for virus cell entry. Conformational masking of V3 within …
The role of the human Duffy antigen receptor for chemokines in malaria susceptibility: current opinions and future treatment prospects
FB Ntumngia, R Thomson-Luque, CV Pires… - Journal of receptor …, 2016 - Taylor & Francis
The Duffy antigen receptor for chemokine (DARC) is a nonspecific receptor for several
proinflammatory cytokines. It is homologous to the G-protein chemokine receptor …
proinflammatory cytokines. It is homologous to the G-protein chemokine receptor …
Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing
The intestinal mucosa is a key anatomical site for HIV-1 replication and CD4+ T cell
depletion. Accordingly, in vivo treatment with an antibody to the gut-homing integrin α4β7 …
depletion. Accordingly, in vivo treatment with an antibody to the gut-homing integrin α4β7 …
Glycan modulation and sulfoengineering of anti–HIV-1 monoclonal antibody PG9 in plants
Broadly neutralizing anti–HIV-1 monoclonal antibodies, such as PG9, and its derivative RSH
hold great promise in AIDS therapy and prevention. An important feature related to the …
hold great promise in AIDS therapy and prevention. An important feature related to the …
[HTML][HTML] V2-directed vaccine-like antibodies from HIV-1 infection identify an additional K169-binding light chain motif with broad ADCC activity
Antibodies that bind residue K169 in the V2 region of the HIV-1 envelope correlated with
reduced risk of infection in the RV144 vaccine trial but were restricted to two ED-motif …
reduced risk of infection in the RV144 vaccine trial but were restricted to two ED-motif …
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
N Friedrich, E Stiegeler, M Glögl, T Lemmin… - Nature …, 2021 - nature.com
The V3 loop of the HIV-1 envelope (Env) protein elicits a vigorous, but largely non-
neutralizing antibody response directed to the V3-crown, whereas rare broadly neutralizing …
neutralizing antibody response directed to the V3-crown, whereas rare broadly neutralizing …