Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Type I interferons have been suspected for decades to have a crucial role in the
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …

The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin,
is incompletely understood. Here we demonstrate, using a combination of single cell and …

Whereas the cellular and molecular features of human inflammatory skin diseases are well
characterized, their tissue context and systemic impact remain poorly understood. We thus …

Systemic lupus erythematosus (SLE) is a severe chronic systemic autoimmune disease
caused by complicated interactions among genetic, epigenetic, and immunological factors …

The term fibroblast has been used generally to describe spindle-shaped stromal cells of
mesenchymal origin that produce extracellular matrix, establish tissue structure, and form …

Systemic lupus erythematosus (SLE) is an autoimmune disease that has diverse clinical
manifestations, ranging from restricted cutaneous involvement to life-threatening systemic …

Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various
organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus …

Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive
production and accumulation of extracellular matrix, leading to fibrosis of skin and other …

Discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) are both types
of lupus, yet the characteristics, and differences between them are not fully understood. Here …