Covering: 1966 to the beginning of 2009The Securinega alkaloids are a small family of plant
metabolites with fascinating bridged tetracyclic structures and significant biological activity …

The extract of the pericarp of castor bean (Ricinus communis) showed some typical central
nervous system stimulant effects when administered to mice. The animals became …

A new strategy for enantiospecific construction of the Securinega alkaloids has been
developed and applied in total syntheses of (+)-14, 15-dihydronorsecurinine (8),(−) …

A consecutive synthetic strategy was developed toward the total synthesis of securinega
alkaloids.(−)-Norsecurinine was concisely assembled by addition of a methoxyallene to a …

Alles fügt sich zusammen: Die meisten der bisherigen Synthesen der Securinega‐Alkaloide
erforderten längere Sequenzen zum Aufbau der verbrückenden Butenolid‐Domäne. Ein …

We addressed the role of nitric oxide (NO) in orexin neuron degeneration that has been
observed under various pathological conditions. Administration of an NO donor NOC18 (50 …

We evaluated in Sprague–Dawley rats anaesthetized with propofol the engagement of
soluble guanylyl cyclase (sGC)/cGMP cascade, glutamatergic and GABAergic …

The first enantioselective total syntheses of virosaine A and bubbialidine are described. Key
transformations include the formation of a tetracyclic intermediate via an intramolecular aza …

Employing computational methods and published data from molecular biological studies
involving amino acid sequences in the polypeptide receptors, the authors studied and …

Three new Securinega alkaloids, secu'amamines B− D (1–3), were isolated from the wood
of the Japanese medicinal plant Securinega suffruticosa var. amamiensis, together with five …