Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Mesenchymal stem cell (MSC) chondrogenesis in three-dimensional (3D) culture involves
dynamic changes in cytoskeleton architecture during mesenchymal condensation before …

Cell migration on two-dimensional substrates is typically characterized by lamellipodia at the
leading edge, mature focal adhesions and spread morphologies. These observations result …

Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Cell migration is an essential process, both in unicellular organisms such as amoeba and as
individual or collective motility in highly developed multicellular organisms like mammals. It …

Although the biological functions of cell and tissue can be regulated by biochemical factors
(eg, growth factors, hormones), the biophysical effects of materials on the regulation of …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …