Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as
constitutive and alternative splicing regulators. As splicing is linked to transcriptional and …

Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized
extensively to generate the pattern of mRNAs needed to specify cell types and to respond to …

Thousands of mutations are identified yearly. Although many directly affect protein
expression, an increasing proportion of mutations is now believed to influence mRNA …

Circular RNAs (circRNAs) have emerged as key regulators of human cancers, yet their
modes of action in gastric cancer (GC) remain largely unknown. Here, we identified circURI1 …

The diversity of distinct covalent forms of proteins (the proteome) greatly exceeds the
number of proteins predicted by DNA coding capacities owing to directed posttranslational …

Point mutations frequently cause genetic diseases by disrupting the correct pattern of pre-
mRNA splicing. The effect of a point mutation within a coding sequence is traditionally …

Both microRNAs and alternative pre-mRNA splicing have been implicated in the
development of the nervous system (NS), but functional interactions between these two …

In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …

Proteomics is the study of the function of all expressed proteins. Tremendous progress has
been made in the past few years in generating large-scale data sets for protein–protein …

The molecular diversification of cell surface molecules has long been postulated to impart
specific surface identities on neuronal cell types. The existence of unique cell surface …