Maternal immunological adaptation during normal pregnancy
The risk and severity of specific infections are increased during pregnancy due to a
combination of physiological and immunological changes. Characterizing the maternal …
combination of physiological and immunological changes. Characterizing the maternal …
[HTML][HTML] An overview of autoantibodies in rheumatoid arthritis
MAM van Delft, TWJ Huizinga - Journal of autoimmunity, 2020 - Elsevier
Rheumatoid arthritis (RA) is a systemic auto-immune disease principally effecting synovial
joints. RA is characterized by immune cell infiltration in the joint. The presence of …
joints. RA is characterized by immune cell infiltration in the joint. The presence of …
Fc glycans of therapeutic antibodies as critical quality attributes
D Reusch, ML Tejada - Glycobiology, 2015 - academic.oup.com
Critical quality attributes (CQA) are physical, chemical, biological or microbiological
properties or characteristics that must be within an appropriate limit, range or distribution to …
properties or characteristics that must be within an appropriate limit, range or distribution to …
The state-of-play and future of antibody therapeutics
Z Elgundi, M Reslan, E Cruz, V Sifniotis… - Advanced drug delivery …, 2017 - Elsevier
It has been over four decades since the development of monoclonal antibodies (mAbs)
using a hybridoma cell line was first reported. Since then more than thirty therapeutic …
using a hybridoma cell line was first reported. Since then more than thirty therapeutic …
The history of IgG glycosylation and where we are now
BA Cobb - Glycobiology, 2020 - academic.oup.com
IgG glycosylation is currently at the forefront of both immunology and glycobiology, likely due
in part to the widespread and growing use of antibodies as drugs. For over four decades, it …
in part to the widespread and growing use of antibodies as drugs. For over four decades, it …
Therapeutic antibodies for autoimmunity and inflammation
The development of therapeutic antibodies has evolved over the past decade into a
mainstay of therapeutic options for patients with autoimmune and inflammatory diseases …
mainstay of therapeutic options for patients with autoimmune and inflammatory diseases …
Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements
Nearly 30% of currently approved recombinant therapeutic proteins are produced in
Escherichia coli. Due to its well-characterized genetics, rapid growth and high-yield …
Escherichia coli. Due to its well-characterized genetics, rapid growth and high-yield …
Advances in antibody design
KE Tiller, PM Tessier - Annual review of biomedical engineering, 2015 - annualreviews.org
The use of monoclonal antibodies as therapeutics requires optimizing several of their key
attributes. These include binding affinity and specificity, folding stability, solubility …
attributes. These include binding affinity and specificity, folding stability, solubility …
Chemoenzymatic conjugation of toxic payloads to the globally conserved N-glycan of native mAbs provides homogeneous and highly efficacious antibody–drug …
R Van Geel, MA Wijdeven, R Heesbeen… - Bioconjugate …, 2015 - ACS Publications
A robust, generally applicable, nongenetic technology is presented to convert monoclonal
antibodies into stable and homogeneous ADCs. Starting from a native (nonengineered) …
antibodies into stable and homogeneous ADCs. Starting from a native (nonengineered) …
Immunoglobulin G (IgG) Fab glycosylation analysis using a new mass spectrometric high-throughput profiling method reveals pregnancy-associated changes
A Bondt, Y Rombouts, MHJ Selman… - Molecular & Cellular …, 2014 - ASBMB
The N-linked glycosylation of the constant fragment (Fc) of immunoglobulin G has been
shown to change during pathological and physiological events and to strongly influence …
shown to change during pathological and physiological events and to strongly influence …