Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting
humans and a major source for hospital infections associated with high morbidity and …

Antibiotic resistance has increased markedly in gram-negative bacteria over the last two
decades, and in many cases has been associated with increased mortality and healthcare …

Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in
1996. Since then, these versatile β-lactamases have spread internationally among Gram …

Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now
threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae …

This article provides a comprehensive review of currently available treatment options for
infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance …

Multilocus sequence typing reveals that many bacterial species have a clonal structure and
that some clones are widespread. This underlying phylogeny was not revealed by pulsed …

From early this decade, Enterobacteriaceae that produce Klebsiella pneumoniae
carbapenemases (KPC) were reported in the USA and subsequently worldwide. These KPC …

Extended-spectrum β-lactamases (ESBLs) are a rapidly evolving group of β-lactamases
which share the ability to hydrolyze third-generation cephalosporins and aztreonam yet are …

Carbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability
to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria …

Genetic structures surrounding the carbapenem-hydrolyzing Ambler class A bla KPC gene
were characterized in several KPC-positive Klebsiella pneumoniae and Pseudomonas …