Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
[HTML][HTML] Interactome networks and human disease
M Vidal, ME Cusick, AL Barabási - Cell, 2011 - cell.com
Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …
phenotype relationships. Here, we review basic concepts in network biology, discussing …
Independently evolved virulence effectors converge onto hubs in a plant immune system network
MS Mukhtar, AR Carvunis, M Dreze, P Epple… - science, 2011 - science.org
Plants generate effective responses to infection by recognizing both conserved and variable
pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells …
pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells …
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection
R Bartenschlager, V Lohmann, F Penin - Nature Reviews Microbiology, 2013 - nature.com
The availability of the first molecular clone of the hepatitis C virus (HCV) genome allowed
the identification and biochemical characterization of two viral enzymes that are targets for …
the identification and biochemical characterization of two viral enzymes that are targets for …
HPIDB 2.0: a curated database for host–pathogen interactions
MG Ammari, CR Gresham, FM McCarthy, B Nanduri - Database, 2016 - academic.oup.com
Identification and analysis of host–pathogen interactions (HPI) is essential to study infectious
diseases. However, HPI data are sparse in existing molecular interaction databases …
diseases. However, HPI data are sparse in existing molecular interaction databases …
Recent advances in predicting and modeling protein–protein interactions
Protein–protein interactions (PPIs) drive biological processes, and disruption of PPIs can
cause disease. With recent breakthroughs in structure prediction and a deluge of genomic …
cause disease. With recent breakthroughs in structure prediction and a deluge of genomic …
Hepatitis C virus proteins: from structure to function
D Moradpour, F Penin - Hepatitis C virus: from molecular virology to …, 2013 - Springer
Great progress has been made over the past years in elucidating the structure and function
of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as …
of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as …
The dependence of viral RNA replication on co-opted host factors
PD Nagy, J Pogany - Nature Reviews Microbiology, 2012 - nature.com
Abstract Positive-sense RNA ((+) RNA) viruses such as hepatitis C virus exploit host cells by
subverting host proteins, remodelling subcellular membranes, co-opting and modulating …
subverting host proteins, remodelling subcellular membranes, co-opting and modulating …
[HTML][HTML] A novel aux/IAA28 signaling cascade activates GATA23-dependent specification of lateral root founder cell identity
Background Lateral roots are formed at regular intervals along the main root by recurrent
specification of founder cells. To date, the mechanism by which branching of the root system …
specification of founder cells. To date, the mechanism by which branching of the root system …
Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics
DL Diamond, AJ Syder, JM Jacobs… - PLoS …, 2010 - journals.plos.org
Proteomic and lipidomic profiling was performed over a time course of acute hepatitis C
virus (HCV) infection in cultured Huh-7.5 cells to gain new insights into the intracellular …
virus (HCV) infection in cultured Huh-7.5 cells to gain new insights into the intracellular …