Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

[HTML][HTML] Interactome networks and human disease

M Vidal, ME Cusick, AL Barabási - Cell, 2011 - cell.com
Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

Independently evolved virulence effectors converge onto hubs in a plant immune system network

MS Mukhtar, AR Carvunis, M Dreze, P Epple… - science, 2011 - science.org
Plants generate effective responses to infection by recognizing both conserved and variable
pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells …

The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection

R Bartenschlager, V Lohmann, F Penin - Nature Reviews Microbiology, 2013 - nature.com
The availability of the first molecular clone of the hepatitis C virus (HCV) genome allowed
the identification and biochemical characterization of two viral enzymes that are targets for …

HPIDB 2.0: a curated database for host–pathogen interactions

MG Ammari, CR Gresham, FM McCarthy, B Nanduri - Database, 2016 - academic.oup.com
Identification and analysis of host–pathogen interactions (HPI) is essential to study infectious
diseases. However, HPI data are sparse in existing molecular interaction databases …

Recent advances in predicting and modeling protein–protein interactions

J Durham, J Zhang, IR Humphreys, J Pei… - Trends in biochemical …, 2023 - cell.com
Protein–protein interactions (PPIs) drive biological processes, and disruption of PPIs can
cause disease. With recent breakthroughs in structure prediction and a deluge of genomic …

Hepatitis C virus proteins: from structure to function

D Moradpour, F Penin - Hepatitis C virus: from molecular virology to …, 2013 - Springer
Great progress has been made over the past years in elucidating the structure and function
of the hepatitis C virus (HCV) proteins, most of which are now actively being pursued as …

The dependence of viral RNA replication on co-opted host factors

PD Nagy, J Pogany - Nature Reviews Microbiology, 2012 - nature.com
Abstract Positive-sense RNA ((+) RNA) viruses such as hepatitis C virus exploit host cells by
subverting host proteins, remodelling subcellular membranes, co-opting and modulating …

[HTML][HTML] A novel aux/IAA28 signaling cascade activates GATA23-dependent specification of lateral root founder cell identity

B De Rybel, V Vassileva, B Parizot, M Demeulenaere… - Current Biology, 2010 - cell.com
Background Lateral roots are formed at regular intervals along the main root by recurrent
specification of founder cells. To date, the mechanism by which branching of the root system …

Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics

DL Diamond, AJ Syder, JM Jacobs… - PLoS …, 2010 - journals.plos.org
Proteomic and lipidomic profiling was performed over a time course of acute hepatitis C
virus (HCV) infection in cultured Huh-7.5 cells to gain new insights into the intracellular …