Hepadnaviruses, including human hepatitis B virus (HBV), replicate through reverse
transcription of an RNA intermediate, the pregenomic RNA (pgRNA). Despite this kinship to …

Hepatitis B virus (HBV), the causative agent of B-type hepatitis in humans, is the type
member of the Hepadnaviridae, hepatotropic DNA viruses that replicate via reverse …

Chronic hepatitis B virus (HBV) infection remains a major health problem worldwide. The
covalently closed circular DNA (cccDNA) minichromosome, which serves as the template for …

Hepatitis B virus (HBV) infection affects approximately 300 million people worldwide.
Although antiviral therapies have improved the long-term outcomes, patients often require …

Chronic hepatitis B virus (HBV) infection, a serious public health problem leading to cirrhosis
and hepatocellular carcinoma, is currently treated with either pegylated alpha interferon …

Hallmarks of the hepadnavirus replication cycle are the formation of covalently closed
circular DNA (cccDNA) and the reverse transcription of a pregenomic RNA (pgRNA) in core …

Hepatitis B virus (HBV) replicates its DNA genome through reverse transcription of a viral
RNA pregenome. We report herein that the interferon (IFN) stimulated exoribonuclease …

Hepatitis B virus (HBV), which was discovered in 1965, is a threat to global public health.
HBV infects human hepatocytes and leads to acute and chronic liver diseases, and there is …

Hepatitis B virus (HBV) infection is one of the major global health problems, especially in
economically under-developed or developing countries. HBV infection can lead to a number …

Hepatitis B virus infection affects over 250 million chronic carriers, causing more than
800,000 deaths annually, although a safe and effective vaccine is available. Currently used …