The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Dynamic interactions between gut microbiota and a host's innate and adaptive immune
systems are essential in maintaining intestinal homeostasis and inhibiting inflammation. Gut …

An estimated 30–40% of cancers can be prevented through changes in modifiable lifestyle
and environmental risk factors known to be associated with cancer incidence. Despite this …

Adipose tissue is the primary site of storage for excess energy as triglyceride and it helps in
synthesizing a number of biologically active compounds that regulate metabolic …

The pathology of type 2 diabetes is complex, with multiple stages culminating in a functional
β‐cell mass that is insufficient to meet the body's needs. Although the broad outlines of the …

High‐intensity interval training (HIIT) is characterised by short bouts of high‐intensity
submaximal exercise interspersed with rest periods. Low‐volume HIIT, typically involving …

The burden of obesity has increased globally over the last few decades and its association
with insulin resistance and related cardio-metabolic problems have adversely affected our …

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with various contributing
factors including genetics, epigenetics, environment and lifestyle such as diet. The hallmarks …

INTRODUCTION Obesity and its associated complications are serious global concerns.
Despite growing public health initiatives, obesity rates continue to rise. Thus, there is a …

In obesity, excessive abdominal fat, especially the accumulation of visceral adipose tissue
(VAT), increases the risk of metabolic disorders, such as type 2 diabetes mellitus (T2DM) …