Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Mitochondria are complex intracellular organelles traditionally identified as the
powerhouses of eukaryotic cells due to their central role in bioenergetic metabolism. In …

Mitochondrial disorders are characterized by a broad clinical spectrum. Identical clinical
signs and symptoms can be caused by mutations in different mitochondrial or nuclear …

Synaptic plasticity in the adult brain is believed to represent the cellular mechanisms of
learning and memory. Mitochondria are involved in the regulation of the complex processes …

Triggering receptor expressed on myeloid cells 2 (Trem2) is a myeloid cell-specific gene
expressed in brain microglia, with variants that are associated with neurodegenerative …

Mitochondrial dysfunction is a common feature of many genetic disorders that target the
brain and cognition. However, the exact role these organelles play in the etiology of such …

Although developmental delays affect learning, language, and behavior, some evidence
suggests the presence of disturbances in metabolism are associated with psychiatric …

The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a
challenge for the worldwide healthcare system. With the plethora of information from …

Down syndrome (DS) is mostly caused by a trisomy of the entire Chromosome 21 (Trisomy
21, T21). Here, we use SWATH mass spectrometry to quantify protein abundance and …