Cholesterol and components of the cholesterol biosynthetic pathway have fundamental
roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as …

Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …

Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps
of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians …

Background: Cross-talk between sterol metabolism and inflammatory pathways has been
demonstrated to significantly affect the development of atherosclerosis. Cholesterol …

The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an
essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3 …

Abstract X-linked adrenoleukodystrophy (X-ALD), caused by an ABCD1 mutation, is a
progressive neurodegenerative disorder associated with the accumulation of very long …

Oxysterols are cholesterol metabolites generated in the liver and other peripheral tissues as
a mechanism of removing excess cholesterol. Oxysterols have a wide range of biological …

The lipid composition of pulmonary surfactant is unlike that of any other body fluid. This
extracellular lipid reservoir is also uniquely susceptible by virtue of its direct and continuous …

Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse
roles in the control of cellular processes that go beyond the control of cholesterol …

Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …