The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that
regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural …

Human papillomaviruses (HPVs), which belong to the Papillomaviridae family, constitute a
group of small nonenveloped double-stranded DNA viruses. HPV has a small genome that …

Although Wnt/β-catenin pathway activation has been implicated in mouse models of breast
cancer, there is contradictory evidence regarding its importance in human breast cancer. In …

Abstract Mucin 1 (MUC1) is a heterodimeric protein formed by two subunits that is aberrantly
overexpressed in human breast cancer and other cancers. Historically, much of the early …

An understanding of the process by which tumor cells destroy the basement membrane of
the surface epithelium, invade, and metastasize is essential to the development of novel …

Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and
inactivates the retinoblastoma protein and promotes progression through the G1-S phase of …

Aberrant β-catenin expression as determined by assessment of its subcellular localization
constitutes a surrogate marker of Wnt signalling pathway activation and has been reported …

Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast
cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor …

Essential for embryonic development, the polycomb group protein enhancer of zeste
homolog 2 (EZH2) is overexpressed in breast and prostate cancers and is implicated in the …

Cervical cancer is the fourth most frequent cancer in women worldwide and a major cause of
mortality in developing countries. Persistent infection with high-risk human papillomavirus …