Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

SC Dyall, L Balas, NG Bazan, JT Brenna… - Progress in lipid …, 2022 - Elsevier
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …

Adipocyte regulation of insulin sensitivity and the risk of type 2 diabetes

A Santoro, BB Kahn - New England Journal of Medicine, 2023 - Mass Medical Soc
Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

R Patel, A Santoro, P Hofer, D Tan, M Oberer… - Nature, 2022 - nature.com
Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …

Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function

E Brennan, P Kantharidis, ME Cooper… - Nature Reviews …, 2021 - nature.com
Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …

Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

A Yang, EP Mottillo - Biochemical Journal, 2020 - portlandpress.com
Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …

Understanding FAHFAs: From structure to metabolic regulation

K Brejchova, L Balas, V Paluchova, M Brezinova… - Progress in lipid …, 2020 - Elsevier
The discovery of branched fatty acid esters of hydroxy fatty acids (FAHFAs) in humans draw
attention of many researches to their biological effects. Although FAHFAs were originally …

Lipid remodeling of adipose tissue in metabolic health and disease

YK Cho, S Lee, J Lee, J Doh, JH Park… - … & Molecular Medicine, 2023 - nature.com
Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in
energy homeostasis and endocrine function. Recent advancements in lipidomics techniques …

Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides

K Brejchova, FPW Radner, L Balas… - Proceedings of the …, 2021 - National Acad Sciences
Branched esters of palmitic acid and hydroxy stearic acid are antiinflammatory and
antidiabetic lipokines that belong to a family of fatty acid (FA) esters of hydroxy fatty acids …

Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health

M Riecan, V Paluchova, M Lopes, K Brejchova… - Pharmacology & …, 2022 - Elsevier
Fatty acid esters of hydroxy fatty acids (FAHFAs) represent a complex lipid class that
contains both signaling mediators and structural components of lipid biofilms in humans …

Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs)

P Aryal, I Syed, J Lee, R Patel, AT Nelson… - Journal of lipid …, 2021 - ASBMB
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous lipids with
antidiabetic and anti-inflammatory effects. Each FAHFA family consists of esters with …