Animal models of obesity and diabetes mellitus

M Kleinert, C Clemmensen, SM Hofmann… - Nature Reviews …, 2018 - nature.com
More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Advancements and challenges in generating accurate animal models of gestational diabetes mellitus

RC Pasek, M Gannon - American Journal of Physiology …, 2013 - journals.physiology.org
The maintenance of glucose homeostasis during pregnancy is critical to the health and well-
being of both the mother and the developing fetus. Strikingly, approximately 7% of human …

A Western‐style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in mice

B Musial, OR Vaughan… - The Journal of …, 2017 - Wiley Online Library
Key points In the Western world, obesogenic diets containing high fat and high sugar
(HFHS) are commonly consumed during pregnancy, although their effects on the …

Feeding of fish oil and medium-chain triglycerides to canines impacts circulating structural and energetic lipids, endocannabinoids, and non-lipid metabolite profiles

MI Jackson, DE Jewell - Frontiers in Veterinary Science, 2023 - frontiersin.org
Introduction The effect of medium-chain fatty acid-containing triglycerides (MCT), long-chain
polyunsaturated fatty acid-containing triglycerides from fish oil (FO), and their combination …

Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy: lessons from animal models

AN Sferruzzi-Perri, J Lopez-Tello, T Napso, HEJ Yong - Placenta, 2020 - Elsevier
Pregnancy is a remarkable physiological state, during which the metabolic system of the
mother adapts to ensure that nutrients are made available for transfer to the fetus for growth …

Fructose, pregnancy and later life impacts

TRH Regnault, S Gentili, O Sarr… - Clinical and …, 2013 - Wiley Online Library
Fructose is an increasingly common constituent of the Westernized diet due to cost and
production efficiencies. Although an integral component of our pre‐industrial revolution diet …

Research progress on the experimental animal model of gestational diabetes mellitus

Y He, N Wu, W Yu, L Li, H OuYang, X Liu… - Diabetes, Metabolic …, 2020 - Taylor & Francis
Gestational diabetes mellitus (GDM) refers to different degrees of abnormal glucose
metabolism during pregnancy, where blood glucose levels do not reach the level of overt …

Developmental origins of ovarian disorder: impact of maternal lean gestational diabetes on the offspring ovarian proteome in mice

KL Clark, OO Talton, S Ganesan… - Biology of …, 2019 - academic.oup.com
Gestational diabetes mellitus (GDM) is an obstetric disorder affecting approximately 10% of
pregnancies. The four high-fat, high-sucrose (HFHS) mouse model emulates GDM in lean …

Guidelines for in vivo models of developmental programming of cardiovascular risk

JP Warrington, HE Collins… - American Journal …, 2024 - journals.physiology.org
Research utilizing animals depends on the generation of offspring for use in experiments or
for the maintenance of animal colonies. While not considered by all, several different factors …

Large animal models in the study of gynecological diseases

M Cui, Y Liu, X Men, T Li, D Liu, Y Deng - Frontiers in Cell and …, 2023 - frontiersin.org
Gynecological diseases are a series of diseases caused by abnormalities in the female
reproductive organs or breast, which endanger women's fertility and even their lives …