Animal models of obesity and diabetes mellitus
More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
Advancements and challenges in generating accurate animal models of gestational diabetes mellitus
RC Pasek, M Gannon - American Journal of Physiology …, 2013 - journals.physiology.org
The maintenance of glucose homeostasis during pregnancy is critical to the health and well-
being of both the mother and the developing fetus. Strikingly, approximately 7% of human …
being of both the mother and the developing fetus. Strikingly, approximately 7% of human …
A Western‐style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in mice
B Musial, OR Vaughan… - The Journal of …, 2017 - Wiley Online Library
Key points In the Western world, obesogenic diets containing high fat and high sugar
(HFHS) are commonly consumed during pregnancy, although their effects on the …
(HFHS) are commonly consumed during pregnancy, although their effects on the …
Feeding of fish oil and medium-chain triglycerides to canines impacts circulating structural and energetic lipids, endocannabinoids, and non-lipid metabolite profiles
MI Jackson, DE Jewell - Frontiers in Veterinary Science, 2023 - frontiersin.org
Introduction The effect of medium-chain fatty acid-containing triglycerides (MCT), long-chain
polyunsaturated fatty acid-containing triglycerides from fish oil (FO), and their combination …
polyunsaturated fatty acid-containing triglycerides from fish oil (FO), and their combination …
Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy: lessons from animal models
AN Sferruzzi-Perri, J Lopez-Tello, T Napso, HEJ Yong - Placenta, 2020 - Elsevier
Pregnancy is a remarkable physiological state, during which the metabolic system of the
mother adapts to ensure that nutrients are made available for transfer to the fetus for growth …
mother adapts to ensure that nutrients are made available for transfer to the fetus for growth …
Fructose, pregnancy and later life impacts
TRH Regnault, S Gentili, O Sarr… - Clinical and …, 2013 - Wiley Online Library
Fructose is an increasingly common constituent of the Westernized diet due to cost and
production efficiencies. Although an integral component of our pre‐industrial revolution diet …
production efficiencies. Although an integral component of our pre‐industrial revolution diet …
Research progress on the experimental animal model of gestational diabetes mellitus
Y He, N Wu, W Yu, L Li, H OuYang, X Liu… - Diabetes, Metabolic …, 2020 - Taylor & Francis
Gestational diabetes mellitus (GDM) refers to different degrees of abnormal glucose
metabolism during pregnancy, where blood glucose levels do not reach the level of overt …
metabolism during pregnancy, where blood glucose levels do not reach the level of overt …
Developmental origins of ovarian disorder: impact of maternal lean gestational diabetes on the offspring ovarian proteome in mice
Gestational diabetes mellitus (GDM) is an obstetric disorder affecting approximately 10% of
pregnancies. The four high-fat, high-sucrose (HFHS) mouse model emulates GDM in lean …
pregnancies. The four high-fat, high-sucrose (HFHS) mouse model emulates GDM in lean …
Guidelines for in vivo models of developmental programming of cardiovascular risk
JP Warrington, HE Collins… - American Journal …, 2024 - journals.physiology.org
Research utilizing animals depends on the generation of offspring for use in experiments or
for the maintenance of animal colonies. While not considered by all, several different factors …
for the maintenance of animal colonies. While not considered by all, several different factors …
Large animal models in the study of gynecological diseases
M Cui, Y Liu, X Men, T Li, D Liu, Y Deng - Frontiers in Cell and …, 2023 - frontiersin.org
Gynecological diseases are a series of diseases caused by abnormalities in the female
reproductive organs or breast, which endanger women's fertility and even their lives …
reproductive organs or breast, which endanger women's fertility and even their lives …