The roles of CD8+ T cell subsets in antitumor immunity
MS Paul, PS Ohashi - Trends in cell biology, 2020 - cell.com
Effector CD8+ T cells are typically thought to be a homogenous group of cytotoxic cells that
produce interferon-(IFN) γ. However, recent findings have challenged this notion because …
produce interferon-(IFN) γ. However, recent findings have challenged this notion because …
[HTML][HTML] Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies
Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of
intensive research because of its crucial role in the pathogenesis of different diseases …
intensive research because of its crucial role in the pathogenesis of different diseases …
Current concepts and advances in graft-versus-host disease immunology
Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …
Chronic graft-versus-host disease: biological insights from preclinical and clinical studies
KPA MacDonald, GR Hill… - Blood, The Journal of the …, 2017 - ashpublications.org
With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor–
mobilized peripheral blood stem cell donor grafts and successful treatment of older …
mobilized peripheral blood stem cell donor grafts and successful treatment of older …
Safety, antitumor activity, and immune activation of pegylated recombinant human interleukin-10 (AM0010) in patients with advanced solid tumors
Purpose Interleukin-10 (IL-10) stimulates the expansion and cytotoxicity of tumor-infiltrating
CD8+ T cells and inhibits inflammatory CD4+ T cells. Pegylation prolongs the serum …
CD8+ T cells and inhibits inflammatory CD4+ T cells. Pegylation prolongs the serum …
Cytokines and costimulation in acute graft-versus-host disease
GR Hill, M Koyama - Blood, The Journal of the American …, 2020 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …
therapy for high-risk hematological malignancies, but the development of severe and/or …
[HTML][HTML] IL-17+ CD8+ T cells: differentiation, phenotype and role in inflammatory disease
The pro-inflammatory cytokine interleukin-17A (IL-17) has been the subject of research by
many groups worldwide. IL-17 expression is often associated with a specific subset of CD4+ …
many groups worldwide. IL-17 expression is often associated with a specific subset of CD4+ …
Increased IL‐10‐producing regulatory T cells are characteristic of severe cases of COVID‐19
J Neumann, T Prezzemolo… - Clinical & …, 2020 - Wiley Online Library
Objectives The pandemic spread of the coronavirus SARS‐CoV‐2 is due, in part, to the
immunological properties of the host–virus interaction. The clinical presentation varies from …
immunological properties of the host–virus interaction. The clinical presentation varies from …
[HTML][HTML] Reprint of: acute graft-versus-host disease: novel biological insights
Graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality
after allogeneic hematopoietic stem cell transplantation. Recent insights into intestinal …
after allogeneic hematopoietic stem cell transplantation. Recent insights into intestinal …
Polyfunctional, proinflammatory, Tissue‐Resident memory phenotype and function of synovial Interleukin‐17A+ CD 8+ T cells in psoriatic arthritis
Objective Genetic associations imply a role for CD 8+ T cells and the interleukin‐23 (IL‐
23)/IL‐17 axis in psoriatic arthritis (PsA) and other spondyloarthritides (SpA). IL‐17A+ CD …
23)/IL‐17 axis in psoriatic arthritis (PsA) and other spondyloarthritides (SpA). IL‐17A+ CD …