Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Wound healing is a physiological process, involving three successive and overlapping
phases—hemostasis/inflammation, proliferation, and remodeling—to maintain the integrity …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an
intriguing subject of study for their complex structural characteristics, their finely regulated …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …

Matrix metalloproteinases are a family of zinc-dependent endopeptidases that are involved
in a large variety of proteolytic processes in physiological and pathological scenarios …

Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol,
preventing the development of atherosclerosis. We previously demonstrated that membrane …

Abstract Increased T helper (Th) 1/Th17 immune responses are a hallmark of Crohn's
disease (CD) immunopathogenesis. CD90+ (myo-) fibroblasts (MFs) are abundant cells in …

Matrix metalloproteinases hydrolyze proteins and glycoproteins forming the extracellular
matrix, cytokines and growth factors released in the extracellular space, and membrane …

Proteolytic processing shapes cellular interactions with the environment. As a pathway of
unconventional protein secretion, ectodomain shedding releases soluble proteoforms of …