[HTML][HTML] A comprehensive overview on stress neurobiology: basic concepts and clinical implications

LD Godoy, MT Rossignoli, P Delfino-Pereira… - Frontiers in behavioral …, 2018 - frontiersin.org
Stress is recognized as an important issue in basic and clinical neuroscience research,
based upon the founding historical studies by Walter Canon and Hans Selye in the past …

The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights

W Lazarini-Lopes, RA Do Val-da Silva… - Neuroscience & …, 2020 - Elsevier
Epilepsy is a neurological disorder characterized by the presence of seizures and
neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of …

Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity

MS Hester, SC Danzer - Journal of Neuroscience, 2013 - Soc Neuroscience
Accumulation of abnormally integrated, adult-born, hippocampal dentate granule cells
(DGCs) is hypothesized to contribute to the development of temporal lobe epilepsy (TLE) …

The role of stress as a trigger for epileptic seizures: a narrative review of evidence from human and animal studies

B Novakova, PR Harris, A Ponnusamy, M Reuber - Epilepsia, 2013 - Wiley Online Library
Stress is one of the most frequently self‐identified seizure triggers in patients with epilepsy;
however, most previous publications on stress and epilepsy have focused on the role of …

Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility

G MacKenzie, J Maguire - Epilepsy research, 2015 - Elsevier
The most commonly reported precipitating factor for seizures is stress. However, the
underlying mechanisms whereby stress triggers seizures are not yet fully understood. Here …

Epilepsy associated depression: an update on current scenario, suggested mechanisms, and opportunities

T Singh, RK Goel - Neurochemical Research, 2021 - Springer
Depression is one of the most frequent psychiatric comorbidities associated with epilepsy
having a major impact on the patient's quality of life. Several screening tools are available to …

The Wistar Audiogenic Rat (WAR) strain and its contributions to epileptology and related comorbidities: history and perspectives

N Garcia-Cairasco, EHL Umeoka, JAC de Oliveira - Epilepsy & Behavior, 2017 - Elsevier
In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar
Audiogenic Rat (WAR), first introduced to the neuroscience international community more …

Hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy

T Basu, J Maguire, JA Salpekar - Neuroscience letters, 2021 - Elsevier
Stress is a common seizure trigger in persons with epilepsy. The body's physiological
response to stress is mediated by the hypothalamic-pituitary-adrenal (HPA) axis and …

Saracatinib, a Src tyrosine kinase inhibitor, as a disease modifier in the rat DFP model: sex differences, Neurobehavior, gliosis, neurodegeneration, and nitro-oxidative …

M Gage, M Putra, L Wachter, K Dishman, M Gard… - Antioxidants, 2021 - mdpi.com
Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure
causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective …

Stress and seizures: space, time and hippocampal circuits

BG Gunn, TZ Baram - Trends in neurosciences, 2017 - cell.com
Stress is a major trigger of seizures in people with epilepsy. Exposure to stress results in the
release of several stress mediators throughout the brain, including the hippocampus, a …