Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders

JA Jiménez, MJ Zylka - Journal of neurodevelopmental disorders, 2021 - Springer
Research with rodents is crucial for expanding our understanding of genetic and
environmental risk factors for neurodevelopmental disorders (NDD). However, there is …

Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring

AK Short, KA Fennell, VM Perreau, A Fox… - Translational …, 2016 - nature.com
Recent studies have suggested that physiological and behavioral traits may be
transgenerationally inherited through the paternal lineage, possibly via non-genomic signals …

Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour

AP Harris, MC Holmes, ER De Kloet… - …, 2013 - Elsevier
An imbalance between central glucocorticoid (GR) and mineralocorticoid (MR) receptors is
proposed to underlie the HPA axis dysregulation that associates with susceptibility to …

Human gestational N‐methyl‐d‐aspartate receptor autoantibodies impair neonatal murine brain function

B Jurek, M Chayka, J Kreye, K Lang, L Kraus… - Annals of …, 2019 - Wiley Online Library
Objective Maternal autoantibodies are a risk factor for impaired brain development in
offspring. Antibodies (ABs) against the NR1 (GluN1) subunit of the N‐methyl‐d‐aspartate …

[HTML][HTML] Parenting behaviors in mice: olfactory mechanisms and features in models of autism spectrum disorders

A Dudas, TS Nakahara, LP Pellissier… - … & Biobehavioral Reviews, 2024 - Elsevier
Rodents, along with numerous other mammals, heavily depend on olfactory cues to
navigate their social interactions. Processing of olfactory sensory inputs is mediated by …

Direct and transgenerational effects of low doses of perinatal di-(2-ethylhexyl) phthalate (DEHP) on social behaviors in mice

KM Quinnies, EP Harris, RW Snyder, SS Sumner… - PLoS …, 2017 - journals.plos.org
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disrupting chemical commonly used as a
plasticizer in medical equipment, food packaging, flooring, and children's toys. DEHP …

Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor …

SP Zoubovsky, S Hoseus, S Tumukuntala… - Translational …, 2020 - nature.com
Postpartum depression (PPD) affects up to 20% of mothers and has negative consequences
for both mother and child. Although exposure to psychosocial stress during pregnancy and …

Enduring consequences of perinatal fentanyl exposure in mice

JB Alipio, AT Brockett, ME Fox, SS Tennyson… - Addiction …, 2021 - Wiley Online Library
Opioid use by pregnant women is an understudied consequence associated with the opioid
epidemic, resulting in a rise in the incidence of neonatal opioid withdrawal syndrome …

Effects of maternal stress and perinatal fluoxetine exposure on behavioral outcomes of adult male offspring

V Kiryanova, SJ Meunier, HA Vecchiarelli, MN Hill… - Neuroscience, 2016 - Elsevier
Women of child-bearing age are the population group at highest risk for depression. In
pregnant women, fluoxetine (Flx) is the most widely prescribed selective serotonin reuptake …

Increased aggression, improved spatial memory, and reduced anxiety-like behaviour in adult male mice exposed to fluoxetine early in life

V Kiryanova, RH Dyck - Developmental neuroscience, 2014 - karger.com
Abstract Rationale: Fluoxetine (Flx; brand names Prozac, Sarafem, Rapiflux), a selective
serotonin reuptake inhibitor, is prescribed for the treatment of depression in pregnant …