Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …

Evidence from observational studies and randomized trials suggests that prediabetes and
type 2 diabetes mellitus (T2DM) can develop in genetically susceptible individuals in …

Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

Growing evidence implicates the brain in the regulation of both immediate fuel availability
(for example, circulating glucose) and long-term energy stores (that is, adipose tissue mass) …

Brain glucose metabolism, including glycolysis, the pentose phosphate pathway, and
glycogen turnover, produces ATP for energetic support and provides the precursors for the …

Historically, pancreatic islet beta cells have been viewed as principal regulators of glycemia,
with type 2 diabetes (T2D) resulting when insulin secretion fails to compensate for …

The primary aim was to systematically review the current evidence investigating if dietary
interventions rich in protein lead to improved body weight management in adults with …

The brain, particularly the ventromedial hypothalamic nucleus (VMH), has been long known
for its involvement in glucose sensing and whole-body glucose homeostasis. However, it is …

Neonatal hypoglycemia is a common condition. A transient reduction in blood glucose
values is part of a transitional metabolic adaptation following birth, which resolves within the …

“Relative hypoglycemia” is an often-overlooked complication of diabetes characterized by
an increase in the glycemic threshold for detecting and responding to hypoglycemia. The …