Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Histone deacetylases (HDACs) play an important role in regulating target gene expression.
They have been highlighted as a novel category of anticancer targets, and their inhibition …

Cereblon (CRBN) is a primary target of thalidomide and mediates its multiple
pharmacological activities, including teratogenic and antimyeloma activities. CRBN …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

The p63 gene is a member of the p53/p63/p73 family of transcription factors and plays a
critical role in development and homeostasis of squamous epithelium. p63 is transcribed as …

Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular
plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) …

Histone deacetylases (HDACs) deacetylate histones H3 and H4. An imbalance between
histone acetylation and deacetylation can lead to various diseases. HDAC2 is present in the …

Cancer cells must adapt to the hostile conditions of the microenvironment in terms of
nutrition, space, and immune system attack. Mutations of DNA are the drivers of the …

It is now well recognized that mutations, deregulated expression, and aberrant recruitment of
epigenetic readers, writers, and erasers are fundamentally important processes in the onset …

The lysine acetyltransferases play crucial but complex roles in cancer development. GCN5
is a lysine acetyltransferase that generally regulates gene expression, but its role in cancer …