[HTML][HTML] SARS-CoV-2 Vaccines: The Advantage of Mucosal Vaccine Delivery and Local Immunity

J Tobias, P Steinberger, J Wilkinson, G Klais, M Kundi… - Vaccines, 2024 - mdpi.com
Immunity against respiratory pathogens is often short-term, and, consequently, there is an
unmet need for the effective prevention of such infections. One such infectious disease is …

Rapid detection of sars-cov-2 rna using reverse transcription recombinase polymerase amplification (Rt-rpa) with lateral flow for n-protein gene and variant-specific …

JL Malaga, MJ Pajuelo, M Okamoto, EK Tsinda, K Otani… - Viruses, 2023 - mdpi.com
Rapid molecular testing for severe acute respiratory coronavirus 2 (SARS-CoV-2) variants
may contribute to the development of public health measures, particularly in resource-limited …

Crystal structures of main protease (Mpro) mutants of SARS-CoV-2 variants bound to PF-07304814

H Jiang, X Zou, P Zeng, X Zeng, X Zhou, J Wang… - Molecular …, 2023 - Springer
There is an urgent need to develop effective antiviral drugs to prevent the viral infection
caused by constantly circulating SARS-CoV-2 as well as its variants. The main protease …

[HTML][HTML] Global burden of new-onset hypertension associated with severe acute respiratory syndrome coronavirus 2 infection

F Angeli, M Zappa, P Verdecchia - European journal of internal medicine, 2024 - Elsevier
Several reports documented a specific effect of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) on blood pressure (BP), during and after the acute phase of …

The old and the new: The EG. 5 ('Eris') sub-variant of Coronavirus

M Zappa, P Verdecchia, A Andolina… - European Journal of …, 2023 - ejinme.com
In the last year of pandemic, several variants of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) have been identified and monitored. Indeed, the persisting …

SARS‐CoV‐2 XBB. 1.16 variant: India in focus?

R Varghese, S Pai, D Kumar… - Journal of Medical …, 2023 - search.ebscohost.com
Until February 2023, the majority of COVID-19 cases were associated with SARS-CoV-2
subvariants, such as BF. 7,[1] BQ. 1,[1] BQ. 1.1,[1] and XBB. 1.5,[1] and XBB. 1.9.[2] …

Innovative strategies for targeting furin protease and unraveling the dynamics of orthosteric and structural modulating inhibitors

P Gao, S Luo, Q Wang, B Tang, J Liu, E Zhang… - Journal of Molecular …, 2024 - Elsevier
Central to the pathogenicity of SARS-CoV-2 is the spike (S) protein, which relies on furin
protease and TMPRSS2 to recognize and cleave the sequence to complete the invasion of …

Impact of mutations in SARS-CoV-2 recombinant sub-variant XBB. 1.16 on the binding affinity with Human ACE2 receptor

SS Tariq, K Zia, M Nur-e-Alam, D Nerukh… - Journal of Molecular …, 2024 - Elsevier
Despite the waning threat of the COVID-19 pandemic, its detrimental impact on global health
persists. Regardless of natural immunity or immunity obtained through vaccination …

Targeting Multiple Conserved T-Cell Epitopes for Protection against COVID-19 Moderate-Severe Disease by a Pan-Sarbecovirus Vaccine

CY Wang, BS Kuo, YH Lee, YH Ho, YH Pan, YT Yang… - medRxiv, 2023 - medrxiv.org
Background Most of current approved vaccines, based on a Spike-only as single
immunogen, fall short of producing a full-blown T-cell immunity. SARS-CoV-2 continues to …

Why Should Vaccines against Respiratory Diseases Go Mucosal? B Cell Epitope-Based Vaccines against SARS-CoV-2

J Tobias, P Steinberger, J Wilkinson, G Klais, M Kundi… - 2024 - preprints.org
Immunity against respiratory pathogens is often short-term, and consequently there is an
unmet need for effective prevention of such infections. One such infectious disease is COVID …