Gastrointestinal (GI) dysfunction is common in the critical care setting and is highly
associated with clinical outcomes. Opioids increase the risk for GI dysfunction and are …

This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …

Background Constipation incidence and impact remain controversial in the ICU. This may
depend on the definition criterion used in the previous studies on the field. We aimed to …

Purpose There are several causes for delayed constipation in critically ill patients.
Constipation in critically ill patients is reportedly associated with poor outcomes. However, a …

阿片类药物相关性便秘(opioid-induced constipation, OIC) 是阿片类药物应用过程中最常见的
不良反应, 其困扰着癌痛患者和医务工作者, 影响癌痛患者的疼痛控制. 因此, 控制OIC …

Constipation is a frequent problem in intensive care unit (ICU) patients, 1, 2 but is often
overlooked. Staff often react more quickly to diarrhea, which is usually obvious, than to …

Background: Opioid-induced constipation (OIC) is common in critically ill patients; it leads to
complications that can increase hospital stay and, rarely, bowel perforation. Opioid …

Opioid antagonists in the ICU are often a last-line medication given to patients with opioid-
induced constipation. Traditionally, patients have been administered nonopioid-based …

Background Opioid-induced constipation (OIC) is the most prevalent side effect of
methadone maintenance therapy (MMT). Naloxone could reduce the OIC. Method Fifty-six …

Background: Opioid-induced constipation (OIC) may occur in up to 81% of critically ill
patients and can lead to many complications. Opioid antagonists are a reasonable approach …