Antifungal potential of the new copper(II)-theophylline/1,10-phenanthroline complex against drug-resistant Candida species
HF Frota, CMA Lorentino, PF Barbosa, LS Ramos… - Biometals, 2024 - Springer
Candida spp. are the commonest fungal pathogens worldwide. Antifungal resistance is a
problem that has prompted the discovery of novel anti-Candida drugs. Herein, 25 …
problem that has prompted the discovery of novel anti-Candida drugs. Herein, 25 …
Synthesis, structural characterization, and DNA binding/cleavage studies of diorganotin (IV) carboxylates and their complexes with 1, 10-phenanthroline: X-ray …
The present study is focused on the mode of DNA-interactions with diorganotin (IV)
carboxylates and their 1, 10-phenanthroline (phen) complexes, and revealed that the …
carboxylates and their 1, 10-phenanthroline (phen) complexes, and revealed that the …
[HTML][HTML] Can Mn coordination compounds be good candidates for medical applications?
S Kozieł, D Wojtala, M Szmitka, J Sawka… - Frontiers in Chemical …, 2024 - frontiersin.org
Metal centres provide unique foci for varied biological modes of action that often but not
exclusively involve redox or metal-ligand reactions. Metal complexes offer alternative and …
exclusively involve redox or metal-ligand reactions. Metal complexes offer alternative and …
Study on computer screening and drug properties of herbs intervening in copper death
Z Dayuan, L Lan, C Hui, L Huanjie… - … Methods in Medicine, 2023 - Wiley Online Library
Objective. The objective of this study was to explore the medicinal properties of herbal
medicines that can interfere with the copper death pathway. Methods. The Human Gene …
medicines that can interfere with the copper death pathway. Methods. The Human Gene …
Novel Metallomacrocyclic Carboxamide Mn (II) Complexes as Efficient Catalysts for the Transfer Hydrogenation of Ketones
Herein, we present the first metallomacrocyclic Mn (II) complexes as efficient catalysts for the
transfer hydrogenation of ketones. The dinuclear Mn (II) complexes [Mn2 (L1–L4) 2Cl2](Mn1 …
transfer hydrogenation of ketones. The dinuclear Mn (II) complexes [Mn2 (L1–L4) 2Cl2](Mn1 …
[HTML][HTML] Cu(II)-Catalysed Hydrocarboxylation of Imines Utilizing CO2 to Synthesize α-Unsaturated Aminocarboxylic Acids
AT Gordon, EC Hosten, AS Ogunlaja - Pharmaceuticals, 2022 - mdpi.com
Here, we report the Cu (II)-photocatalysed hydrocarboxylation of imines (C= N) from a series
of synthesized Schiff Base derivatives, namely (E)-1-(4-((4-methylbenzylidene) amino) …
of synthesized Schiff Base derivatives, namely (E)-1-(4-((4-methylbenzylidene) amino) …
[HTML][HTML] An 8-aminoquinoline-naphthyl copper complex causes apoptotic cell death by modulating the expression of apoptotic regulatory proteins in breast cancer …
Breast cancer is one of the most common cancers globally and a leading cause of cancer-
related deaths among women. Despite the combination of chemotherapy with targeted …
related deaths among women. Despite the combination of chemotherapy with targeted …
Unveiling the antifungal mechanisms of CTP, a new copper(II)-theophylline/1,10-phenanthroline complex, on drug-resistant non-albicans Candida species
HF Frota, PF Barbosa, CMA Lorentino, LRF Affonso… - BioMetals, 2024 - Springer
Candida species undeniably rank as the most prevalent opportunistic human fungal
pathogens worldwide, with Candida albicans as the predominant representative. However …
pathogens worldwide, with Candida albicans as the predominant representative. However …
DNA binding/cleavage study of mixed ligand complexes of di-/triorganotin 4-fluroanthranilates with 1, 10-phenanthroline/benzimidazole: Synthesis, characterization, X …
The mixed ligand complexes of di-/tri-organotin 4-fluoroanthranilates with 1, 10-
phenanthroline (phen), viz.[R 2 Sn (FA) 2. phen]{R= Bu (1), Oct (2), Me (3)} and …
phenanthroline (phen), viz.[R 2 Sn (FA) 2. phen]{R= Bu (1), Oct (2), Me (3)} and …
Copper(II)-photocatalyzed Hydrocarboxylation of Schiff bases with CO2: antimicrobial evaluation and in silico studies of Schiff bases and unnatural α-amino acids
AT Gordon, EC Hosten, S van Vuuren… - Journal of …, 2024 - Taylor & Francis
We synthesized and characterized two copper (II) complexes:[CuL2Cl] Cl and [CuL′ 2Cl]
Cl, where L= 2, 2'-bipyridine and L′= 4, 4'-dimethyl-2, 2'-bipyridine. We evaluated their …
Cl, where L= 2, 2'-bipyridine and L′= 4, 4'-dimethyl-2, 2'-bipyridine. We evaluated their …